Asian Journal of Research in Pharmaceutical Sciences

Smita S. Aher ¹, Vaishali D. Sangale ¹, Ravindra B. Saudagar ¹

Affiliations
1 Department of Pharmaceutical Chemistry, KCT’S RGS College of Pharmacy, Anjaneri, Nashik, 422 213, Maharashtra, IN

Abstract

Mucoadhesion could be a field of current interest within the style of drug delivery systems. Mucoadhesive drug delivery system prolongs the continuance of the indefinite quantity kind at the positioning of application or absorption associate degreed facilitates an intimate contact of the indefinite quantity kind with the underline absorption surface and so contributes to improved and higher therapeutic performance of the drug. In recent years several such mucoadhesive drug delivery systems are developed for oral, buccal, nasal, body part and canal routes for each general and native effects.

Issues like high first-pass metabolism and drug degradation within the canal surroundings is circumvented by administering the drug via the buccal route. Moreover, speedy onset of action is achieved relative to the oral route and therefore the formulation is removed if medical care is needed to be out of print. It’s additionally attainable to administer medication to patients UN agency unconscious and fewer co-operative. To forestall accidental swallowing of medicine adhesive tissue layer indefinite quantity forms were advised for oral delivery, including adhesive tablets, adhesive gels, adhesive patches and plenty of alternative indefinite quantity forms with numerous combos of polymers, absorption enhancers. Additionally to the current, studies are conducted on the event of controlled or slow unharness delivery systems for general and native medical care of diseases.

Keywords

Buccal Region, Mucoadhesive, 1st Pass Metabolism.

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Vaishali D. Sangale ¹, Smita S. Aher ², Ravindra B. Saudagar ²

Affiliations
1 Department of Quality Assurance Technique, KCT’S RGS College of Pharmacy, Anjaneri, Nashik, 422 213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, KCT’S RGS College of Pharmacy, Anjaneri, Nashik, 422 213, Maharashtra, IN

Abstract

Orally fast dissolving films are an emerging technology with fast onset of activity and improved patient compliance. It enhances the viability of API's and gives better medication use. These formulations are suitable for cold, allergy rhinitis, asthma attacks, CNS issue where fast onset of activity is needed for quicker help. The sublingual course of medication organization is extremely compelling following the medication retained through the sublingual veins by passes hepatic first pass metabolic procedure and also gives a better bioavailability. The present article outlines the definition viewpoints, manufacturing methods like solvent casting method, evaluation parameters and applications of fast dissolving films by sublingual route It has been estimated that approximately 84% of all sales of the top selling commercially available products are delivered via the oral route. Thin film drug delivery has come forward as an advanced alternative to the traditional tablets, capsules and liquids frequently associated with prescription and OTC medications. Similar in size, shape, and thickness to a postage stamp, thin film strips are classically designed for oral administration, with the user placing the strip on or under the tongue(sublingual)or along the inside of the cheeks(buccal).These drug delivery options allows the medication to bypass the first pass metabolism thereby making the medication further available. As the strip dissolves, the drug can enter the blood stream enterically, buccally or sublingually. The permeation is superior with sublingual than buccal than palatal region.

Keywords

Fast Dissolving Drug Delivery, Oral Strips, Sublingual Film, Mouth Dissolve.

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Lankesh P. Shewale ¹, Sheetal B. Gondkar ¹, Ravindra B. Saudagar ², Avinash B. Dareker ¹

Affiliations
1 Department of Pharmaceutics, Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN

Abstract

The objective of this study was to design matrix tablets for oral sustained release of clopidogrel bisulfate and to investigate the sustained release behavior of the matrix tablets. Matrices were prepared by direct compression technique, melt method and microencapsulation using sodium carboxymethylcellulose, carnuba wax and ethyl cellulose as a release retardant. The FT-IR analysis indicated the stability and compatibility of drug with excipients. The formulation was optimized on the basis of acceptable tablet properties and invitro drug release. The resulting formulations produced tablets with optimum hardness, uniform thickness, consistent weight uniformity and low friability. The results of dissolution studies indicated that formulations F2 batch exhibited good drug release pattern to provide sufficient concentration for achieving satisfactory therapeutic value for extended period of time. The drug release from F2 formulation was sustained upto 12 hrs. Tablet Fitting in-vitro drug release data from optimized matrix formulation to Korsmeyer Pappas model equation indicated that diffusion and erosion could be mechanism of drug release. Matrix tablet F2 showed no change in physical appearance, drug content after storage 40°C, 75% RH for 3 months.

Keywords

Matrix Tablet, Release Retardant, Diffusion, Clopidogrel Bisulfate.

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Smita S. Aher ¹, Poonam R. Songire ², Ravindra B. Saudagar ¹

Affiliations
1 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
2 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN

Abstract

A sustained release matrix formulation for Albuterol Sulphate was designed and developed to achieve a 12 h release profile. Using HPMC K15M and HPMC K100M as an inert matrix forming agent to control the release of Albuterol Sulphate. The matrix tablets for these formulations were prepared by direct compression and their in-vitro release tests were carried out for a period of 12 hours using USP dissolution test apparatus (type II Paddle) at 37±0.5°C and 50 rpm speed. A 3² full factorial design was used for optimization by taking the concentration of HPMC K15M (X1) and HPMC K100M (X2) were selected as independent variables, whereas initial release at the (Y1, % drug release), (Y2, % drug Content) the concentration of Were chosen as dependent variables. The optimized formulation F9 follows Higuchi model and Korsemeyer - Pappas release kinetics with non- Fickian diffusion mechanism. From the study, it was concluded that the release of Albuterol Sulphate can be effectively controlled using combination of HPMC K15M, HPMC K 100M and Carbopol 940.

Keywords

Albuterol Sulphate, Gelucire43/01, Melt Method, Direct Compression Method, Factorial Design.

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Rajashri R. Kulkarni ¹, Dipti G. Phadtare ², Ravindra B. Saudagar ²

Affiliations
1 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN

Abstract

Analytical methods development and validation play important roles in the discovery, development, and manufacture of pharmaceuticals. Simple, precise and accurate UV spectroscopic method has been developed and validated for estimation of Fluticasone propionate. It is a selective agonist at the glucocorticoid receptor. UV spectroscopic method which is based on measurement of absorption of UV light, the spectra of Fluticasone propionate in methanol showed maximum wavelength at 236nm and calibration curve were plotted over the concentrations ranging from 2-22ug/ml of Fluticasone propionate with correlation coefficient 0.9812 validation was performed as per ICH Q2 (R1) guidelines for linearity, accuracy, precision and recovery. The proposed method was validated.

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Nikhil P. Mahalpure ¹, Sheetal B. Gondkar ¹, Ravindra B. Saudagar ²

Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN

Abstract

Conventional oral drug delivery systems supply continues release of drug, which cannot release of the drug and effective concentration at the target site. Drug can be delivered in a controlled manner over a long period of time by the process of osmosis. Osmotic devices are the most promising technique for controlled drug delivery. Osmotic drug delivery system is one among the controlled drug delivery employed orally and also as an implantable devices. Various patents available for osmotic drug delivery system like Rose-Nelson pump, Higuchi leeper pump, Higuchi Theeuwes pump, Elementary Osmotic pump etc. various techniques available for preparation of Osmotic Drug Delivery System include Push pull osmotic pump, Osmotic bursting osmotic pump, Liquid oral osmotic system, Sandwiched osmotic tablets, monolithic osmotic system and Controlled porosity osmotic pump. The present review is concerned with the study of drug release system which are tablets coated with walls of controlled porosity. When these system are exposed to water, low levels of water soluble additives is leached from polymeric material i.e. semi permeable membrane and drug releases in a controlled manner over an extended period of time. Drug delivery from this system is not influenced by the different physiological factors within the gut lumen and the release characteristics can be predicted easily from the known properties of the drug and the dosage form. In this paper, various type of osmotically controlled drug delivery systems and mainly the basic components and evaluation parameter of controlled porosity osmotic pump tablets have been discussed briefly.

Keywords

Osmotic Pump, Controlled-Porosity Osmotic Pump Tablet, Semi Permeable Membrane, Osmogent, Leachable Pore Formers.

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Swapnil R. Lahamage ¹, Avinash B. Darekar ¹, Ravindra B. Saudagar ²

Affiliations
1 Department of Pharmaceutics, KCT'S R.G. Sapkal College of Pharmacy, Anjenari, Dist. Nashik-422212, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, KCT'S R.G. Sapkal College of Pharmacy, Anjenari, Dist. Nashik-422212, Maharashtra, IN

Abstract

Co-crystal consists of API and a stoichiometric amount of a pharmaceutically acceptable co-crystal former. Pharmaceutical Co-crystal is non-ionic supramolecular complexes and can be used to address physical property issues such as solubility, stability and bioavailability in pharmaceutical development without changing the chemical composition of the API. Co-crystal is a crystalline entity formed by two different or more molecular entities where the intermolecular interactions are weak forces like hydrogen bonding and π-π stacking. Super porous systems, biodegradable hydrogel systems. Co crystallization alters the molecular interaction and composition of pharmaceutical materials, and is considered better alternative to optimize drug properties. The article gives brief review on the co-crystallization, selection of appropriate co former and preparation of co crystals, different techniques of co-crystallization, physicochemical properties, characterization and applications.

Keywords

Pharmaceutical Co-Crystal, Method of Preparation, Characterization of Co-Crystal, and Applications.

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Nachiket S. Dighe ¹, Ravindra B. Saudagar ², Ramesh S. Kalkotwar ³, D. A. Jain ⁴

Affiliations
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni, MS -413736, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Nashik, M.S, IN
3 Department of Pharmaceutical Chemistry, S.N.D. College of Pharmacy, Yeola, Dist-Nashik, MS, IN
4 Department of Pharmaceutical Sciences and Research, Bhagwant University, Ajmer, Rajasthan, IN

Abstract

Mercaptooxadiazole is a five membered heterocyclic system consists of two nitrogen and one oxygen atoms along with acidic thiol group. As it increases the acidity of the titled compounds. It can be easily synthesized from hydazides using potassium hydroxide in presence of carbon disulphide. Mercaptooxadiazoles posses wide spectrum of biological activities like antibacterial, antifungal, antiviral, anti-inflammatory, anticonvulsant, antidepressant, antihypertensive, analgesic, and hypoglycemic properties. The present review is an attempt made to reveal the therapeutic and synthetic profiles of the mercaptooxadiazole ring.

Keywords

Mercaptooxadiazole, Synthesis, Biological Evaluation.

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