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Pandey, R.
- Orally Disintegrating Tablets:A Complete Review on Methodology
Authors
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, CG, IN
2 Columbia Institute of Pharmacy, Tekari, Raipur, CG, IN
3 Shree Rawatpura Institute of Pharmaceutical Sciences, Kumahari, Dist. Durg CG, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 3, No 4 (2013), Pagination: 161-169Abstract
An Orally Disintegrating tablets (ODT) is a solid-dosage form that disintegrates and dissolves in the mouth without water within 60 seconds or less. The techniques applied are direct compression, sublimation and melt granulation technique. These techniques are based on the principles of increasing porosity or addition of super disintegrants and water soluble excipient in the tablets. The formulation prepared from this technique differ each other on the basis of the factors like mechanical strength of final product, drug, and dosage form stability, mouth feel , rate of dissolution of the formulation in saliva ,rate of absorption from saliva and overall drug bioavailability. These innovations may involve modifying formulation composition and processing to achieve new performance end-points or the merger of new technological advances with traditional pharmaceutical processing techniques for the production of novel mouth oral disintegrating dosage forms.Keywords
Orally Disintegrating Tablets, Bioavailability, Saliva, Sublimation.- Importance of Pharmacovigilance in Indian Pharmaceutical Industry
Authors
1 Columbia Institute of Pharmacy, Raipur (C.G.), IN
2 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.), IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 2, No 1 (2012), Pagination: 4-8Abstract
Pharmacovigilance is the pharmacological science relating to the detection, assessment, understanding and prevention of adverse effects, particularly long term and short term side effects of medicines. It is the science of collecting, monitoring, researching, assessing and evaluating information from healthcare providers and patients on the adverse effects of medications, biological products, herbalism and traditional medicines with a view to:
Identifying new information about hazards associated with medicines Preventing harm to patients.
Phase IV of the evaluation of a drug starts when the marketing license is granted and extends over many years. It consists of pharmacoepidemiological studies to evaluate the effectiveness, safety, and utilization of the drug in large populations, under real-life conditions. The results confirm or disprove the effectiveness of the drug in clinical practice (confirmation of the therapeutic effect), determine whether approved uses should be expanded or restricted, any untoward interactions (pharmacovigilance) and pharmacoeconomics of the drugs.