Asian Journal of Research in Pharmaceutical Sciences

S. J. Dharwal ¹, S. S. Shukla ², R. Pandey ², Astha Verma ³, Veena D. Thakur ¹, Shikha Shrivastava ¹, Mukesh Nag ¹, Shatish Patel ¹

Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, CG, IN
2 Columbia Institute of Pharmacy, Tekari, Raipur, CG, IN
3 Shree Rawatpura Institute of Pharmaceutical Sciences, Kumahari, Dist. Durg CG, IN

Abstract

An Orally Disintegrating tablets (ODT) is a solid-dosage form that disintegrates and dissolves in the mouth without water within 60 seconds or less. The techniques applied are direct compression, sublimation and melt granulation technique. These techniques are based on the principles of increasing porosity or addition of super disintegrants and water soluble excipient in the tablets. The formulation prepared from this technique differ each other on the basis of the factors like mechanical strength of final product, drug, and dosage form stability, mouth feel , rate of dissolution of the formulation in saliva ,rate of absorption from saliva and overall drug bioavailability. These innovations may involve modifying formulation composition and processing to achieve new performance end-points or the merger of new technological advances with traditional pharmaceutical processing techniques for the production of novel mouth oral disintegrating dosage forms.

Keywords

Orally Disintegrating Tablets, Bioavailability, Saliva, Sublimation.

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