Asian Journal of Research in Pharmaceutical Sciences

Dibyajyoti Saha ¹, Milan Hait ²

Affiliations
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan, Masturi Road, Bilaspur-495004, (C.G), IN
2 Dept. of Chemistry, Dr. C. V. Raman University, Kargi Road, Kota, Bilaspur, C.G.- 495113, IN

Abstract

DMBA is a polycyclic aromatic hydrocarbon which may be used as cancer initiator and croton oil is used as cancer promoter in murine skin which composed of phorbol esters. Formation of stable DMBA-DNA adduct can lead to the induction of mutation that activate proto-oncogen or inactivate tumor suppressor genes as an important event during tumor initiation. In mouse skin the promotion process like increased cell proliferation, suppression of apoatosis and induction of the production of ROS and RNS that cause increase membrane lipid peroxidation and decrease cellular antioxidant stores. ROS plays an important role in the process of mutagenesis and carcinogenesis specially tumor promotion. The main aim and rationally of this ontological design is very potent for screening of new cancer chemopreventive agents as well as anticancer drug development.

Keywords

Carcinogenesis, Polycyclic Aromatic Hydrocarbon, DMBA, Croton Oil.

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Dibyajyoti Saha ¹, Milan Hait ², Mayukh Jana ³, Suprodip Mandal ³, Utpal Jana ⁴

Affiliations
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan, Masturi Road, Bilaspur- 495004, C.G, IN
2 Dept. of Chemistry, Dr.C.V. Raman University, Kargi Road, Kota, Bilaspur, C.G, IN
3 Dept. of Pharmacy, Bharat Technology, Uluberia-711316, W.B, IN
4 Dept. of Pharmacy, Annamalai University, Annamalai Nagar, IN

Abstract

The compounds or substance which emit radiation and which are used in medicine area called radiopharmaceuticals. Radio opaque substances are those compounds (both inorganic and organic) that have the property of casting a shadow on x-ray films. Radiopharmaceuticals preparations are the preparations containing one or more radionuclides. Radionuclides are radioactive and transform spontaneously into other nuclides. The unstable nuclei undergo spontaneous nuclear changes in order to achieve stability by emitting radiation are called radioisotopes or radionuclides. The radioactive substances disintegrates or decays with the emission of certain particles or certain quantities of energy which is always characteristics of the isotope.The present article gives various ideas about radiations, radioactivity, radioisotopes, radio opaque and contrast media, radioactive pollution as well as quality control and also pharmaceutical applications of radioisotopes.

Keywords

Radiopharmaceuticals, Radio Opaque, Contrast Media, Radioisotopes.

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