Refine your search
Collections
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Paun, J. S.
- Microbubbles - A Promising Ultrasound Tool for Novel Drug Delivery System: A Review
Abstract Views :307 |
PDF Views:2
Authors
Affiliations
1 Department of Pharmaceutics, S. J. Thakkar Pharmacy College, Rajkot, IN
2 Department of Pharmaceutics, Matushree V.B. Manvar College of Pharmacy, Dumiyani, IN
1 Department of Pharmaceutics, S. J. Thakkar Pharmacy College, Rajkot, IN
2 Department of Pharmaceutics, Matushree V.B. Manvar College of Pharmacy, Dumiyani, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 3, No 2 (2013), Pagination: 56-65Abstract
Microbubbles are emerging as important contrast agents for imaging and carriers for targeted drug delivery. Microbubbles designate air or gas filled microspheres suspended in a liquid carrier phase which generally results from the introduction of air or gas. The liquid phase contains surfactants to control the surface properties as well as stability of the bubble. The microbubbles have an average size less than that of red blood cells, so they are capable of penetrating even into the small blood capillaries and releasing drug and genes under the action of ultrasound field after reaching the specific area of interest. Microbubbles in general have a wide variety of applications. However in the biomedical field these are primarily used as diagnostic agents in combination with ultrasound for molecular imaging of various organs and even tumors. These are also proposed for drug and gene delivery to targeted regions in combination with various ligands. Herein, article includes composition, properties, method of preparation, mechanism and application of microbubbles and review recent results on their performance under various imaging and drug delivery scenarios.Keywords
Microbubbles, Contrast Agents, Diagnostic Agents, Ultrasound, Targeted Drug Delivery.
References
- Jain H, Patel P and Patel P. Microbubbles - A potential Ultrasound Tool in Drug Delivery. Asian Journal of Pharmaceutical and Clinical Research. 4 (2); 2011: 7-11.
- Sirsi SR and Borden MA. Microbubble : Compositions, Properties and Biomedical Applications. Bubble Science. Engineering and Technology. 1 (2); 2009: 3-17.
- Marmottant P and Hilgenfeldt S. Controlled Vesicle 54 and Lysis by Single Oscillating bubbles. Nature International Weekly Journal of Science. 423; 2003: 153-156.
- Van A, Kooiman K and Harteveld M. Vibrating Microbubles Poking Individual Cells: Drug Transfer into Cells via Sonoporation. Journal of Controlled Release. 112 (2); 2006: 149-55.
- Ka-Yun NG and Matsunaga TO. Ultrasound Mediated Drug Delivery. In: Binghe Wang. Drug Delivery: Principles and Applications. A John and Sons. New Jersey. 2005.
- Lindner JR, Klibanov AL and Ley K. Targeting Inflammation. Handbook of Biomedical Aspects of Drug Targeting. Kluwer Academic Publishers. 2002.
- Ying Zheng and Zhao AE. Factors that affect the efficiency of antisense oligodeoxy ribonucleotide transfection by insonated gas-filled lipid microbubbles. Journal of Nanoparticle Research. 10; 2008: 449-454.
- Patel R. Microbubble : An ultrasound contrast agent in molecular imaging. Pharma Times. 42; 2008: 40:15.
- Maliwal D. Microbubbles Contrast Agents Using Ultrasound. Research Journal of Pharmacy and Technology. 1 (3); 2008: 15-21.
- Omolola EA and Hammer DA. In Vitro Characterization of Leukocyte Mimetic For Targeting Therapeutics to the Endothelium Using Two Receptors. Biomaterials. 26 (34); 2005: 7136-7144.
- Christiansen C, Kryvi H and Sontum P. Physical and Biochemical Characterization of Albunex: A new Ultrasound Contrast Agent Consisting of Air filled Albumin Microspheres Suspended in a Solution of Human Albumin. Biotehchnology and Applied Biochemistry. 19 (3); 1994: 307-320.
- Myrset AH, Nicolaysen H and Toft K. Structure and Organization of Albumin molecules Forming the cell of Air filled Microspheres: Evidence for A Monolayer of Albumin molecules of multiple Orientations stabilizing the Enclosed Air. Biotehchnology and Applied Biochemistry. 24 (2); 1996: 145- 153.
- Grinstaff MW and Suslick KS. Air filled ProteinaceousMicrobubbles: synthesis of an echo-contrast agent. Proceedings of the National Academy of Sciences of the United states of America. 88 (17); 1991: 7708-7710.
- Dayton PA, Morgan KE and Klibanov AL. Optical and Acoustical Observations of the Effects of Ultrasound on Contrast agents. IEEE Transactions on Ultrasonics ferroelectrics and frequency control. 46 (1); 1996: 220-232.
- Cavalieri F, Ashokkumar M and Grieser F. Ultrasound Synthesis of Stable Functional Lysozyme Microbubbles. Langmuir. 24 (18); 2008: 10078-10083.
- Singhal S, Moser CC and Wheatley MA. Surfactant-stabilized microbubbles as ultrasound contrast Agents: Stability study of Span 60 and Tween 80 mixtures using a Langmuir trough. Langmuir. 9 (9); 1993: 2426-2429.
- Wang WH, Moser CC and Wheatley MA. Microbubble: Composition and Physicochemical Properties. Journal of Physical Chemistry. 100 (17); 1996: 13815-13821.
- Dressaire E, Bee R and Bell D. Interfacial Polygonal Nano patterning of Stable Microbubbles. Journal of Nanoparticle Research. 32; 2008: 1198-1201.
- D'Arrigo JS. Stable Gas in Liquid Emulsions: Production in Natural Waters and Artificial Media. Advance in Colloid and Interface Science. 25; 1986: 201-202.
- Notter RH and Wang Z. Pulmonary surfactant: Physical Chemistry, Physiology and Replacement. Review in Chemical Engineering. 13; 1997: 1-118.
- Epstein PS and Plesset MS. On the Stability of Gas Bubbles in Liquid-Gas Solutions. Journal of Chemical- Physics. 18 (11); 1950: 1505-1509.
- Duncan PB and Needham D. Test of the Epstein - Plesset Model for Gas Micro particle Dissolution in Aqueous Media: Effect of Surface Tension and Gas Undersaturation in Solution. Langmuir. 20 (7); 2004: 2567-2578.
- Morgan KE, Allen JS and Dayton PA. Experimental and theoretical Evaluation of Microbubble behaviour: Effect of transmitted phase and bubble size. IEEE Transactions on Ultrasonic Ferroelectrics and Frequency Control. 47 (6); 2000: 1494-1509.
- Chomas JE, Dayton PA and Donovan M. Thresold of Fragmentation for Ultrasonic Contrast agents. Journal of Biomedical Optics. 6 (2); 2001: 141-150.
- Bloch SH, Wan M and Dayton PA. Optical observation of Lipid and Polymer shelled Ultrasound Microbubble contrast agents. Applied Physics Latter. 84 (4); 2004: 631-633.
- Borden MA, Kruse DE and Caskey CF. Influence of Lipid cell Physicochemical Properties on Ultrasound induced microbubble Destruction. IEEE Transactions on Ultrasonic Ferroelectrics and Frequency Control. 52 (11); 2005: 1992-2002.
- Wheatley MA, Schrope B and Shen P. Contrast agents For diagnostic ultrasound: Development and evaluation of polymer coated microbubble. Biomaterials. 11 (9); 1990: 713-720.
- Bjerknes K, Braenden JU and Braenden JE. Air-filled Polymeric microcapsules from Emulsions containing different Organic Phases. Journal of Microencapsulation. 18 (2); 2001: 159-171.
- Cavalieri F, EI Hamassi A and Chiessi E. Stable Polymeric microballoons as multifunctional device for biomedical uses: synthesis and characterization. Langmuir. 21 (19); 2005: 8758- 8764.
- Eniola AO, Willcox PJ and Hammer DA. Interplay between rolling and firm adhesion elucidated with a cell-free system engineered with two distinct receptor-ligands pairs. Biophysical Journal. 85 (4); 2003: 2720-2731.
- Postema M and Schmitz G. Bubble dynamics involved in ultrasonic imaging. Expert Review of Molecular Diagnostics. 6 (3); 2006: 493-502.
- Yiyao L and Hirakazu M. Encapsulated Ultrasound microbubbles: Therapeutic application in drug/gene delivery. Journal of Controlled Release. 114 (1); 2006: 89-99.
- Bjerknes K and Sonatum PC. Preparation of polymeric microbubbles: formulation studies and product characterization. International Journal of Pharmaceutics. 158 (2); 1997: 129- 136.
- Klibanov AV, Rychak JJ, Yang WC et al. Targeted ultrasound contrast agent for molecular imaging of inflammation in high shear flow. Contrast Media and Molecular Imaging. 1 (6); 2006: 259-266.
- Lentacker I, Geers B and Demeester J. Design and evaluation of doxorubicin-containing microbubbles for ultrasound-triggered doxorubicin delivery: cytotoxicity and mechanisms involved. Molcular Therapy. 18 (1); 2010: 101-108.
- Jong de N and Frinking P. Basic aconstic properties of microbubbles. Echocardiography. 19; 2004: 95-103.
- Jayaweera AR, Edward N and Glasheen WP. In vivo myocardial kinetics of air filled albumin microbubbles during myocardial contrast echocardiography.Comparision with radiolabeled red blood cells. Circulation Research. 74; 1994: 1157-1165.
- Keller MW, Segal SS and Kaul S. The behavior of sonicated albumin microbubbles within the microcirculations,a basis of their use during myocardial contrast echocardiography. Circulation Research. 165; 1989: 458-467.
- Lindner JM and Wei K. Contrast echocardiography, Current Problem in Cardiology. 27; 2002: 454-519.
- Martin JK, Blomley and Cooke JC. Microbubble contrast agents: a new era in ultrasound, BMJ Journal. 322; 2001: 1222- 1245.
- Hernot S and Klibanov AL. Microbubbles in ultrasoundtriggered drug and gene delivery. Advanced Drug Delivery Reviews. 60; 2008: 1153-1166.
- Christiansen JP, French BA and Klibanov AL. Targeted tissue transfection with ultrasound destruction of plasmid bearing cationic microbubbles. Ultrasound in Medicine and Biology. 29 (12); 2003: 1759-1767.
- Lentacker I, De Geest BG and Vandenbroucke RE. Ultrasoundresponsive polymer-coated microbubbles that bind and protect DNA. Langmuir. 22 (17); 2006: 7273-7278.
- Lentacker I, De Smedt SC and Demeester J. Microbubbles which bind and protect DNA against nucleases. Journal of Controlled Release. 116 (2); 2006: 73-75.
- Hauff P, Seemann S and Reszka R. Evaluation of gas-filled microparticles and sonoporation as gene delivery system: feasibility study in rodent tumor models. Radiology. 236 (2); 2005: 572-578.
- El-Sherif DM, Lathia JD and Wheatley MA. Ultrasound degradation of novel polymer contrast agents. Journal of Biomedical Materials Research. 68 (1); 2004: 71-78.
- Blanco D and Alonso MJ. Protein encapsulation and release from poly (lactide-co-glycolide) microspheres: effect of the protein and polymerproperties and of the co-encapsulation of surfactants. European Journal of Pharmaceutics and Biopharmaceutics. 45 (3); 1998: 285-294.
- Rosa GD, Iommelli R and La Rotonda MI. Influence of the coencapsulation of different non-ionic surfactants on the properties of PLGA insulin-loaded microspheres. Journal of Controlled Release. 69 (2); 2000: 283-295.
- Deng DM, Yuan ML and Xiong CD. Optimization of preparative conditions for poly-DL-lactidepolyethylene glycol microspheres with entrapped vibrio cholera antigens. Journal of Controlled Release. 58 (2); 1999: 123-131.
- Li X, Zhang Y and Yan R. Influence of process parameters on the protein stability encapsulated in poly-DLlactidepoly(ethylene glycol) microspheres, Journal of Controlled Release. 68 (1); 2000: 41-52.
- Li X, Deng X and Huang Z. In vitro protein release and degradation of poly-DL-lactide-poly(ethylene glycol) microspheres with entrapped human serum albumin: quantitative evaluation of the factors involved in protein release phases, Pharmaceutical Research. 18 (1); 2001: 117-124.
- Pistel KF and Kissel T. Effects of salt addition on the microencapsulation of proteins using w/o/w double emulsion technique. Journal of microencapsulation. 4; 2000: 467-483.
- Pistel KF, Breitenbach A and Kissel T. Brush-like branched biodegradable polyesters, part III. Protein release from microspheres of poly(vinyl alcohol)-graft-poly(D,L-lactic-coglycolic acid). Journal of Controlled Release. 73 (1); 2001: 7- 20.
- Yang YY, Chia HH and Chung TS. Effect of preparation temperature on the characteristics and release profiles of PLGA microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method. Journal of Controlled Release. 69 (1); 2000: 81-96.
- Lum AF, Borden MA and Dayton PA. Ultrasound radiation force enables targeted deposition of model drug carriers loaded on microbubbles. Journal of Controlled Release. 111 (2); 2006: 128-134.
- Kheirolomoom A, Dayton PA and Lum AF. Acousticallyactivemicrobubbles conjugated to liposomes: characterization of a proposed drug delivery vehicle. Journal of Controlled Release. 118 (3); 2007: 275-284.
- Klibanov AL, Rinkevich D and McConaughy JE. Ultrasoundtriggered release of microbubble-associated material: sitetargeted drug release and deposition, 32nd Annual Symposium on Controlled Release of Bioactive Materials. Honolulu: Controlled Release Society. 2004, p.735.
- Lewis CW, McConaughy JE and Lindner JR, Development of a novel microbubble agent for ultrasound-mediated targeted drug delivery. Journal of Controlled Release. 110 (2); 2004: 511- 517.
- Marmottant P and Hilgenfeldt S. Controlled vesicle deformation and lysis by single oscillating bubbles. Nature. 423; 2003: 153- 156.
- Cao LQ, Armstrong WF and Miller D. Impact of myocardial contrast echocardiography on vascular permeability: an in vivo dose response study of delivery mode, pressure amplitude and contrast dose. Ultrasound in Medicine and Biology. 29 (9); 2003: 1341-1349.
- Skyba DM, Price RJ and Kaul S. Direct in vivovisualization of intravascular destruction of microbubbles by ultrasoundand its local effects on tissue. Circulation. 98 (4); 1998: 290-293.
- Miller DL and Quddus J. Diagnostic ultrasound activation of contrast agent gas bodies induces capillary rupture in mice. Proceedings of National academy of sciences of United States of America. 97 (18); 2000: 10179-10184.
- Ay T, Havaux X and Van Camp G. Destruction of contrast microbubblesby ultrasound: effects on myocardialfunction, coronary perfusionpressure, and microvascular integrity. Circulation. 104 (2); 2001: 461-466.
- Miller DL and Gies RA. Gas-body-based contrast agent enhances vascular bioeffects of 1.09 MHz ultrasound on mouse intestine. Ultrasound in Medicine and Biology. 24 (8); 1998: 1201-1208.
- Li P, Armstrong WF and Miller DL. Impact of myocardial contrast echocardiography on vascular permeability: comparison of three differentcontrast agents. Ultrasound in Medicine and Biology. 30 (1); 2004: 83-91.
- Wible JH, Galen KP and Klibanov AL. Microbubbles induce renal hemorrhage when exposed to diagnostic ultrasound in anesthetized rats. Ultrasound in Medicine and Biology. 28 (12); 2002: 1535-1546.
- Tachibana K and Tachibana S. Albumin microbubble echocontrast materialas an enhancer for ultrasound accelerated thrombolysis, Circulation. 92 (5); 1995: 1148-1150.
- Porter TR, Leveen RF and Fox R. ThrombolyticEnhancement with perfluorocarbon-exposed sonicated dextrose albumin microbubbles. American Heart Journal. 132 (5); 1996: 964- 968.
- Molina CA, Ribo M, and Rubiera M. Microbubble administration accelerates clot lysis duringcontinuous 2-MHz ultrasound monitoring in stroke patients treated with intravenous tissue plasminogen activator. Stroke.37 (2); 2006: 425-42.
- Birnbaum Y, Iakobishvili Z, and Porter A. Microparticlecontaining oncotic solutions augment in-vitro clot disruption by ultrasound, Thrombosis Research. 98 (6); 2000: 549-557.
- McDannold N, Vykhodtseva N, and Raymond S. MRI-guided targeted blood-brain barrier disruption with focused ultrasound. Ultrasound in Medicine and Biology. 31 (11); 2005: 1527- 1537.
- Zhang Y, Tam K and Hynynen K. Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRIguided focused ultrasound. International Journal of Cancer. 121 (4); 2007: 901-907.
- Hynynen K. Focused ultrasound for blood-brain disruption and delivery of therapeutic molecules into the brain. Expert Opinionon Drug Delivery. 4 (1); 2007: 27-35
- Schlachetzki F, Holscher T and Koch HJ. Observation on the integrity of the blood-brain barrier after microbubble destruction by diagnostic transcranialcolorcoded sonography. Journal of Ultrasound in Medicine. 21 (4); 2002: 419-429.
- Lawrie A, Brisken AF and Francis SE. Ultrasound enhances reporter gene expression after transfection of vascular cells in vitro. Circulation. 99 (20); 1999: 2617-2620.
- Ward M, Wu J and Chiu JF. Ultrasound-induced cell lysis and sonoporation enhanced by contrast agents. Journal of the Acoustical Society of America. 105 (5); 1999: 2951-2957.
- Wu J, Ross JP and Chiu JF. Reparable sonoporation generated by microstreaming. Journal of the Acoustical Society of America. 111 (3); 2002: 1460-1464.
- Basta G, Venneri L, and Lazzerini G. In vitro modulation of intracellular oxidative stress of endothelial cells bydiagnostic cardiac ultrasound, Cardiovascular Research. 58 (1); 2003: 156-161.
- Juffermans LJ, Dijkmans PA, and Musters RJ. Transient permeabilization of cell membranes by ultrasound-exposed microbubbles is related to formation of hydrogen peroxide. American Journal ofPhysiology Heart and Circulatory Physiology. 291 (4); 2006: 155-160.
- Kondo T, Misik V and Riesz P. Effect of gas-containing microspheres and echo contrast agents on free radical formation by ultrasound. Free Radical Biology and Medicine. 25 (5); 1998: 605-612.
- Miller DL and Gies RA. The interaction of ultrasonic heating and cavitation in vascular bioeffects on mouse intestine. Ultrasound in Medicine and Biology. 24 (1); 1998: 123-128.
- Bekeredjian R, Chen S and Frenkel PA. Ultrasound-Targeted Microbubble Destruction Can Repeatedly Direct Highly Specific Plasmid Expression to the Heart. Circulation. 108; 2003: 1022- 1026.
- Nishikawa M and Huang L. Nonviral Vectors in the New Millennium: Delivery Barriers in Gene Transfer. Human Gene Therapy. 12 (8); 2001: 861-870.
- Humbert S, Yan F and Frinking P. Ultrasound-mediated gene delivery: influence of contrast agent on transfection. Bioconjugated Chemistry. 18 (3); 2007: 652-662.
- Optimization of Solvents and Processing Conditions for Crystallization of Aceclofenac
Abstract Views :233 |
PDF Views:2
Authors
Affiliations
1 Department of Pharmaceutics, B. K. Mody Govt. Pharmacy College, Rajkot-360003, IN
2 Department of Pharmaceutical Sciences, Saurashtra University, Rajkot – 360005, IN
3 Department of Pharmaceutics, Matushree V. B. Manvar College of Pharmacy, Upleta-360440, IN
1 Department of Pharmaceutics, B. K. Mody Govt. Pharmacy College, Rajkot-360003, IN
2 Department of Pharmaceutical Sciences, Saurashtra University, Rajkot – 360005, IN
3 Department of Pharmaceutics, Matushree V. B. Manvar College of Pharmacy, Upleta-360440, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 3, No 3 (2013), Pagination: 122-132Abstract
Background: Polymorphism is the phenomena where drug exists in more than one crystalline form. Though polymorphs are chemically identical, they exhibit different physicochemical properties like melting point, solubility, dissolution profile etc. which further affect the biological properties of drugs. The purpose of this work was to study the effect of solvents of different polarity and processing conditions on crystallization and physicochemical properties of Aceclofenac.
Methods: The crystals were prepared from different polarity of solvents and processing conditions like deep freezing, law temperature cooling, room temperature cooling etc. The melting point, solubility, dissolution profile, Fourier Transform Infra-Red, Differential Scanning Calorimetry, X-Ray Diffraction and Scanning Electron Microscopy studies were carried out to check for polymorphism in drug. Dissolution kinetic was also studied to compare the dissolution profiles of drug and its crystals.
Result: The result indicate that crystal obtained from different solvents and processing conditions exhibited different physicochemical properties. Though FT-IR and XRD gave an indication of difference in the spectra, but DSC proved absence of any polymorphic behavior in the crystals of aceclofenac.
Conclusion: It was concluded that the crystals with different properties can be obtained by changing solvent polarity and processing conditions.