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Tank, H. M.
- Design Formulation and Evaluation of Reservoir Type Controlled Released Moxifloxacin Hydrochloride Ocular Insert
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Authors
Affiliations
1 S. J. Thakkar Pharmacy College, Opp NRI bungalow, Avadh Club Road, Munjka, Kalawad Road, Rajkot, IN
2 Matushree V B Manvar Pharmacy College, Dumiyani, Upleta, Rajkot, IN
1 S. J. Thakkar Pharmacy College, Opp NRI bungalow, Avadh Club Road, Munjka, Kalawad Road, Rajkot, IN
2 Matushree V B Manvar Pharmacy College, Dumiyani, Upleta, Rajkot, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 3, No 1 (2013), Pagination: 19-24Abstract
The present studies were mainly focus to developed ocular controlled release formulation of Moxifloxacin Hydrochloride. Reservoir type of ocular insert was developed by solvent casting method. Total nine formulations was developed using different ratio of Eudragit RS 100 and Eudragit RL100 in combination as a rate controlling membrane and reservoir was prepared by using sodium CMC. All the prepared formulation were subjected for evaluation of physicochemical parameter like thickness, weight variation, percentage moisture absorption, percentage moisture loss, surface pH, sterility, drug content and anti-microbial activity. Evaluated results were shown that all the prepared formulation was suitable for patient compliance. In-vitro release study was carried out by using commercial semipermeable membrane with the help of modified standard cylindrical tube method and best formulation F7 found 98.21 % at the end of 24 hrs. Formulated ocular inserts also passed the test for sterility. The above in vitro release studies revealed that the best ocular inserts formulation followed near to zero-order release kinetics. Higuchi’s plot and Peppa’s plot revealed that the mechanism of drug release involved in all the formulations was super case II transport diffusion. The antimicrobial study was shown that formulation was able to inhibit the microbial growth for extended period of time. The controlled release ocular insert was more suitable as compared to conventional dosage form.Keywords
Reservoir Drug Delivery System, Ocular Insert, Moxifloxacin Hydrochloride, Eudragit RS100, Eudragit RL 100.
References
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- Enhancement of Solubility and Dissolution Rate of Poorly Water Soluble Drug by Using Modified Guar Gum
Abstract Views :459 |
PDF Views:82
Authors
Vipul V. Jambukiya
1,
Ramesh B. Parmar
1,
Ashvin V. Dudhrejiya
1,
H. M. Tank
1,
Vipul D. Limbachiya
1
Affiliations
1 Dept. of Pharmaceutics, Saurashtra University, Rajkot -360005, IN
1 Dept. of Pharmaceutics, Saurashtra University, Rajkot -360005, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 3, No 1 (2013), Pagination: 25-30Abstract
Introduction: The increasing interest of the technology of dosage form with natural biopolymers has become the reason for undertaking present investigation on the possibility of guar gum application in the preparation of an oral solid dosage form of a poorly water soluble drug.
Method: Present study examines the effect of Guar gum (GG) and Modified guar gum (MGG) on the oral bioavailability of a poorly water-soluble drug, Ibuprofen (IBU). Modified guar gum (MGG) was prepared using heat treatment (125-130oC for 2 to 3 hours) method. It was characterized for viscosity, swelling index and water retention capacity. The physical and co-grinding mixtures of IBU with GG and MGG were prepared in 1:9 drug to gum ratio. The physical and co-grinding mixtures were characterized by DSC and FT-IR study.
Results: The studies confirmed that there was no interaction between drug and carrier. Prepared mixtures were evaluated for solubility study and in vitro dissolution studies using USP XXIII Dissolution apparatus. The rank order of solubility and dissolution study was IBU < grounded IBU < Physical mixture of IBU and GG < Physical mixture of IBU and MGG < Co-grinding mixture of IBU and GG < Co-grinding mixture of IBU and MGG.
Conclusion: The results of present investigation indicated that co-grinding mixture of ibuprofen with modified guar gum could be useful in developing an oral dosage form with improved dissolution and oral bioavailability of poorly water soluble drug.
Keywords
Guar Gum, Modified Guar Gum, Dissolution Rate Enhancement, Poorly Soluble Drug.References
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- Jain S, Yadav SK, Patil UK. Preparation and Evaluation of Sustained Release Matrix Tablet of Furosemide using Natural Polymers. Res J. Pharm.Tech. 2008;1(4):374-376.
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- Microbubbles - A Promising Ultrasound Tool for Novel Drug Delivery System: A Review
Abstract Views :305 |
PDF Views:2
Authors
Affiliations
1 Department of Pharmaceutics, S. J. Thakkar Pharmacy College, Rajkot, IN
2 Department of Pharmaceutics, Matushree V.B. Manvar College of Pharmacy, Dumiyani, IN
1 Department of Pharmaceutics, S. J. Thakkar Pharmacy College, Rajkot, IN
2 Department of Pharmaceutics, Matushree V.B. Manvar College of Pharmacy, Dumiyani, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 3, No 2 (2013), Pagination: 56-65Abstract
Microbubbles are emerging as important contrast agents for imaging and carriers for targeted drug delivery. Microbubbles designate air or gas filled microspheres suspended in a liquid carrier phase which generally results from the introduction of air or gas. The liquid phase contains surfactants to control the surface properties as well as stability of the bubble. The microbubbles have an average size less than that of red blood cells, so they are capable of penetrating even into the small blood capillaries and releasing drug and genes under the action of ultrasound field after reaching the specific area of interest. Microbubbles in general have a wide variety of applications. However in the biomedical field these are primarily used as diagnostic agents in combination with ultrasound for molecular imaging of various organs and even tumors. These are also proposed for drug and gene delivery to targeted regions in combination with various ligands. Herein, article includes composition, properties, method of preparation, mechanism and application of microbubbles and review recent results on their performance under various imaging and drug delivery scenarios.Keywords
Microbubbles, Contrast Agents, Diagnostic Agents, Ultrasound, Targeted Drug Delivery.References
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- Optimization of Solvents and Processing Conditions for Crystallization of Aceclofenac
Abstract Views :230 |
PDF Views:2
Authors
Affiliations
1 Department of Pharmaceutics, B. K. Mody Govt. Pharmacy College, Rajkot-360003, IN
2 Department of Pharmaceutical Sciences, Saurashtra University, Rajkot – 360005, IN
3 Department of Pharmaceutics, Matushree V. B. Manvar College of Pharmacy, Upleta-360440, IN
1 Department of Pharmaceutics, B. K. Mody Govt. Pharmacy College, Rajkot-360003, IN
2 Department of Pharmaceutical Sciences, Saurashtra University, Rajkot – 360005, IN
3 Department of Pharmaceutics, Matushree V. B. Manvar College of Pharmacy, Upleta-360440, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 3, No 3 (2013), Pagination: 122-132Abstract
Background: Polymorphism is the phenomena where drug exists in more than one crystalline form. Though polymorphs are chemically identical, they exhibit different physicochemical properties like melting point, solubility, dissolution profile etc. which further affect the biological properties of drugs. The purpose of this work was to study the effect of solvents of different polarity and processing conditions on crystallization and physicochemical properties of Aceclofenac.
Methods: The crystals were prepared from different polarity of solvents and processing conditions like deep freezing, law temperature cooling, room temperature cooling etc. The melting point, solubility, dissolution profile, Fourier Transform Infra-Red, Differential Scanning Calorimetry, X-Ray Diffraction and Scanning Electron Microscopy studies were carried out to check for polymorphism in drug. Dissolution kinetic was also studied to compare the dissolution profiles of drug and its crystals.
Result: The result indicate that crystal obtained from different solvents and processing conditions exhibited different physicochemical properties. Though FT-IR and XRD gave an indication of difference in the spectra, but DSC proved absence of any polymorphic behavior in the crystals of aceclofenac.
Conclusion: It was concluded that the crystals with different properties can be obtained by changing solvent polarity and processing conditions.