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Sharma, Ashish Kumar
- Effect of Dimethyl Sulphoxides as Permeation Enhancer on Transdermal Patch of Nebivolol Hydrochloride
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PDF Views:90
Authors
Affiliations
1 Department of Pharmaceutics, Gyan Vihar School of Pharmacy, SGVU, Jaipur, IN
2 Department of Pharmaceutical Chemistry, Lordshiva College of Pharmacy, Sirsa, Haryana, IN
1 Department of Pharmaceutics, Gyan Vihar School of Pharmacy, SGVU, Jaipur, IN
2 Department of Pharmaceutical Chemistry, Lordshiva College of Pharmacy, Sirsa, Haryana, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 3, No 1 (2013), Pagination: 8-11Abstract
A matrix type transdermal patch for delivery of Nebivolol hydrochloride (NEB), is unique as a beta-blocker. Studies were carried out to investigate the effect of permeation enhancers on the in vitro permeation of Nebivolol hydrochloride across rat skin. Films were prepared by using Eudragit RS100 (ERS100) and hydroxy propyl methyl cellulose (HPMC K100M) polymers by incorporating polypropylene glycol (PEG 400) as plasticizer using solvent evaporating method. A total of eight formulations were prepared by using same drug and different polymer ratio and some formulation prepared without (E1-E4)/with (F1-F4) Dimethyl sulphoxides (DMSO) as permeation enhancers in same concentrations. The maximum percent of drug permeation was observed with ERS100 and HPMC K100M (2:8) monolithic system containing 20% Dimethyl sulphoxides (F1). The in vitro release studies revealed that Dimethyl sulphoxides showed better permeation enhancement than without DMSO and the release was sustained up to 48 h and it follows higuchi kinetics. All the films were found to be stable at temperature of 40±2°C and 75±5% relative humidity (RH) as per the international conference on harmonization (ICH) guidelines (Zone IV) for the period of six months with respect to their physical parameters.Keywords
Permeation Enhancer, Polymers, Transdermal Patch, Nebivolol Hydrochloride, Dimethyl Sulphoxides.
References
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- Synthesis and Evaluating Anti-Inflammatory, Antibacterial Activity of Substituted Benzylidene Thiazolidinediones
Abstract Views :162 |
PDF Views:2
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, NIMS University, Shobha Nagar, Delhi Highway, Jaipur-303121 (Rajasthan), IN
1 Department of Pharmaceutical Chemistry, NIMS University, Shobha Nagar, Delhi Highway, Jaipur-303121 (Rajasthan), IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 3 (2016), Pagination: 198-202Abstract
This compound we synthesize by a Knoevenagel condensation of 4-aminobenzaldehyde with compound (I) in presence of sodium acetate, but this compound do not comply with the primary aromatic amine test like nitrous acid test and carbylamine test as well as H1 NMR spectra, in this reaction the amine group of benzaldehyde was further reacted another molecules of aldehydes. We modified the process and synthesized compound (Ia), the nitro group of compound Ia was converted in amino group by reduction.Keywords
Thiazolidinedione, Benzaledhyde, Schiff Base.- Assessment of Wound Healing Activity of Roots of Bauhinia variegata Linn. by Excision and Incision Model in Albino Rats
Abstract Views :214 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacy, NIMS Institute of Pharmacy, NIMS University, Jaipur, Rajasthan, IN
2 Department of Pharmacology, KLE’s Colleges of Pharmacy, Rajaji Nagar, Bangaluru, Karnataka, IN
3 Department of Pharmacology, Arya College of Pharmacy, Jaipur, Rajasthan, IN
1 Department of Pharmacy, NIMS Institute of Pharmacy, NIMS University, Jaipur, Rajasthan, IN
2 Department of Pharmacology, KLE’s Colleges of Pharmacy, Rajaji Nagar, Bangaluru, Karnataka, IN
3 Department of Pharmacology, Arya College of Pharmacy, Jaipur, Rajasthan, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 5, No 3 (2015), Pagination: 145-152Abstract
The plant Bauhinia variegata Linn. (Caesalpiniaceae) is commonly known as Mountain Ebony. It is widely used in folklore medicine in treatment of ulcer, to prevent obesity, as an astringent, tonic and in skin diseases. To evaluate the wound healing activity of ethanolic and aqueous extracts of Bauhinia variegata Linn. ischolar_main by excision and incision wound models in rats as there were no scientific reports on its wound healing activity.
Excision and incision wound models were used to evaluate the wound healing activity of both ethanolic and aqueous extracts at 200 and 400 mg/kg b.w. using albino Wistar rats. The wound healing activity was assessed by percentage of wound closure, period of epithelialization, hydroxyproline estimation and histopathological studies of the granulation tissue for excision wound model and incision wound model was evaluated by tensile strength measurement. Treatment with aqueous and ethanolic extracts of ischolar_main of Bauhinia variegata Linn. at both the doses produced significant (P<0.001) wound healing activity. Ethanolic extract produced wound healing activity which was comparable to control in both wound models. The result of wound healing activity was substantiated by the histopathological evaluation. Phenolic content of ethanolic and aqueous extracts were found to be 14.88 and 22.62 μg/mg of pyrocatechol equivalents respectively. The ethanolic and aqueous extracts exhibited significant wound healing activity probably due to the presence of flavonoids.