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Gupta, Akhilesh
- Development and Study of Wound Healing Activity of an Ayurvedic Formulation
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Affiliations
1 Shri Bhagwan College of Pharmacy Aurangabad (M.S.), IN
2 Kunwar Haribansh Singh College of Pharmacy Jaunpur (U.P.), IN
1 Shri Bhagwan College of Pharmacy Aurangabad (M.S.), IN
2 Kunwar Haribansh Singh College of Pharmacy Jaunpur (U.P.), IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 1, No 1 (2011), Pagination: 26-28Abstract
The effect of prepared Ayurvedic formulation was evaluated on excision and incision wound models in rats. The wound-healing activity was assessed by the rate of period of epithelialization and skin-breaking strength. Histological study of the granulation tissue was carried out to know the extent of collagen formation in the wound tissue. The Ayurvedic formulation prepared was then promoted for wound-healing activity in two wound models. The treated animals showed significant reduction in the wound area up to (P<0.001) and faster rate of epithialisation (23.17±0.54). In an incision wound model, formulation treated animals demonstrated significant skin-breaking strength up to 420.33±5.92. Histological studies of the tissue obtained from the formulation treated group revealed that the activity was more significant in this group. Our present study reveals that the Ayurvedic formulation posses potent wound healing activity, which could be a good choice of remedy for wound healing but less potent than standard Nitrofurazone.Keywords
Excision Wound, Incision Wound Model, Ayurvedic Medicinal Plants.
- Plazomicin:A Step Toward Next Generation Aminoglycosides. Review
Abstract Views :161 |
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Affiliations
1 Surgycare Lifescience, Sendhwa (MP), IN
1 Surgycare Lifescience, Sendhwa (MP), IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 7, No 3 (2017), Pagination: 173-180Abstract
Aminoglycosides are selectively active against gram negative bacteria through inhibition of protein synthesis; moreover, those are given parenterally or topically because they are poorly absorbed from the gastrointestinal tract, therefore are given parenterally or topically. Nephrotoxicity and ototoxicity are the most common side effects associated with aminoglycosides therapy. As the resistance developed in most of the bacteria that open the door to use either most toxic combination therapy of present aminoglycosides with other antibiotics such as beta lactams or vancomycin with which they exert a synergistic effect or to discover next generation aminoglycosides, without toxicities. For the discovery of next generation aminoglycosides, a successful step passes through identification of one structure with molecular formula C25H48N6O10 and 592.68 molecular wight from 490 analogous of sisomicin with absence of 3’-OH and 4’-OH groups and named as “ACHN-490” or “Plazomicin” by Achaogen. Plazomicin showed activity against Enterobacteriaceae (EC), Multi drug resistant Enterobacteriaceae (MDR-EC), Aminoglycoside resistant Enterobacteriaceae (AR-EC), Carbapenem resistant Enterobacteriaceae (CR-EC), Colistin resistant (CR-CRE), Tigecycline resistant (TR-EC). Lack of nephrotoxicity or ototoxicity associated with plazomicin; make it drug of future in next generation aminoglycosides. In this review, I am trying to underlying discovery and development of plazomicin as newer antibiotic.Keywords
Next Generation Aminoglycoside, Plazomicin, ACGN-490, Multi-Drug Resistant Enterobacteriaceae, Aminoglycoside Resistance, Aminoglycoside Combination Therapy.References
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