Asian Journal of Research in Pharmaceutical Sciences

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Importance and Utility of Vagina as a Route for Drug Delivery System


Affiliations
1 Columbia Institute of Pharmacy, Tekari, Raipur, India
     

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The purpose of this review article is to highlight the importance of vaginal drug delivery system. Several studies proven that vagina is an effective route for drug administration intended for local action as well as systemic action. This route offers many advantages due to its large permeation area, permeability to large molecular weight drugs, rich vascularization, avoidance of first pass metabolism and relatively low enzymatic activity. Through this route steroidal compounds, spermicidal agents are already delivered to obtain suitable therapeutics action for prolong period of time with minimal side effects. Recently the vaginal route has been investigated for peptide and protein drug delivery. In this review we focused on different aspects related to vaginal drug delivery systems along with their anatomy physiology and factors affecting drug absorption from the vaginal route.

Keywords

Vagina, Intravaginal Route, Peptide and Protein Drug Delivery.
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  • Importance and Utility of Vagina as a Route for Drug Delivery System

Abstract Views: 282  |  PDF Views: 2

Authors

Amit Roy
Columbia Institute of Pharmacy, Tekari, Raipur, India
Ananta Choudhury
Columbia Institute of Pharmacy, Tekari, Raipur, India
Tapan Kishor Nayak
Columbia Institute of Pharmacy, Tekari, Raipur, India

Abstract


The purpose of this review article is to highlight the importance of vaginal drug delivery system. Several studies proven that vagina is an effective route for drug administration intended for local action as well as systemic action. This route offers many advantages due to its large permeation area, permeability to large molecular weight drugs, rich vascularization, avoidance of first pass metabolism and relatively low enzymatic activity. Through this route steroidal compounds, spermicidal agents are already delivered to obtain suitable therapeutics action for prolong period of time with minimal side effects. Recently the vaginal route has been investigated for peptide and protein drug delivery. In this review we focused on different aspects related to vaginal drug delivery systems along with their anatomy physiology and factors affecting drug absorption from the vaginal route.

Keywords


Vagina, Intravaginal Route, Peptide and Protein Drug Delivery.

References