Asian Journal of Research in Pharmaceutical Sciences

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Hepatoprotective Activity of Ardisia solanacea in CCL4 Induced Hepatoxic Albino Rats


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1 SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India
     

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The objective of this study was to investigate the hepatoprotective activity of alcoholic extract of Ardisia solanacea leaves against carbon tetrachloride (CCL4) induced hepatotoxicity. The plant material were dried in shade then powdered and extracted with alcohol. Preliminary phytochemical tests were done. Alcoholic extract showed presence of phenolic compound and flavanoids. The hepatoprotective activity of the alcoholic extract was assessed in CCL4 induced hepatotoxic rats. Alteration in the levels of biochemical markers of hepatic damage like SGOT, SGPT, ALP, Billirubin and Protein were tested in both CCL4 treated and untreated groups. CCL4 (1ml) has enhanced the SGOT, SGPT, ALP and Total Billirubin where decrease in total protein level in liver. Treatment of alcoholic extract of Ardisia Solanacea (200mg/kg) has brought back the altered levels of biochemical markers to the near normal levels in the dose dependent manner. Our findings suggested that Ardisia Solanacea alcoholic leaf extract possessed hepatoprotective activity. Moreover, it prevented CCL4induced prolongation in pentobarbital sleeping time confirming hepatoprotectivity and validates the traditional use of this plant against liver damage.

Keywords

Ardisia solanacea, Hepatoprotective, Silymarin, CCL4, Alcohol.
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  • Hepatoprotective Activity of Ardisia solanacea in CCL4 Induced Hepatoxic Albino Rats

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Authors

Pradeep Kumar Samal
SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India

Abstract


The objective of this study was to investigate the hepatoprotective activity of alcoholic extract of Ardisia solanacea leaves against carbon tetrachloride (CCL4) induced hepatotoxicity. The plant material were dried in shade then powdered and extracted with alcohol. Preliminary phytochemical tests were done. Alcoholic extract showed presence of phenolic compound and flavanoids. The hepatoprotective activity of the alcoholic extract was assessed in CCL4 induced hepatotoxic rats. Alteration in the levels of biochemical markers of hepatic damage like SGOT, SGPT, ALP, Billirubin and Protein were tested in both CCL4 treated and untreated groups. CCL4 (1ml) has enhanced the SGOT, SGPT, ALP and Total Billirubin where decrease in total protein level in liver. Treatment of alcoholic extract of Ardisia Solanacea (200mg/kg) has brought back the altered levels of biochemical markers to the near normal levels in the dose dependent manner. Our findings suggested that Ardisia Solanacea alcoholic leaf extract possessed hepatoprotective activity. Moreover, it prevented CCL4induced prolongation in pentobarbital sleeping time confirming hepatoprotectivity and validates the traditional use of this plant against liver damage.

Keywords


Ardisia solanacea, Hepatoprotective, Silymarin, CCL4, Alcohol.

References