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Synthesis, Characterization and Biological Evaluation of Benzothiazole Derivatives as Potential Antimicrobial and Analgesic Agents


Affiliations
1 Department of Pharmaceutical Chemistry, Hindu College of Pharmacy, Amaravathi Road, Guntur, India
2 Department of Pharm. Chemistry, QIS College of Pharmacy, Ongole-523272, India
     

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Five series of benzothiazole moieties were efficiently synthesized and evaluated for antimicrobial and anticancer activities. The results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms and showed higher activity against fungi than bacteria. Compounds BT-02 exhibited the greatest antimicrobial activity. Preliminary study of the structure-activity relationship revealed that electronic factors in benzothiazole rings had a great effect on the antimicrobial activity of these compounds. The analgesic activity of compounds performed by using tail immersion method. in this case, compound BT-02 shows activity at 100 mg/kg dose 46 ± 0.22, 51 ± 0.22,58 ± 0.43, 48 ± 0.27 at time interval of 30 min,1 hour,2 hour,3 hour respectively compare with the other compounds due to the greater electronic effects.

Keywords

Benzthiazole, Anti Microbial Activity, Tail Immersion Method.
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  • Synthesis, Characterization and Biological Evaluation of Benzothiazole Derivatives as Potential Antimicrobial and Analgesic Agents

Abstract Views: 100  |  PDF Views: 7

Authors

Konda Ravi Kumar
Department of Pharmaceutical Chemistry, Hindu College of Pharmacy, Amaravathi Road, Guntur, India
K. N. S. Karthik
Department of Pharmaceutical Chemistry, Hindu College of Pharmacy, Amaravathi Road, Guntur, India
P. Reshma Begum
Department of Pharmaceutical Chemistry, Hindu College of Pharmacy, Amaravathi Road, Guntur, India
M. M. Prasada Rao
Department of Pharm. Chemistry, QIS College of Pharmacy, Ongole-523272, India

Abstract


Five series of benzothiazole moieties were efficiently synthesized and evaluated for antimicrobial and anticancer activities. The results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms and showed higher activity against fungi than bacteria. Compounds BT-02 exhibited the greatest antimicrobial activity. Preliminary study of the structure-activity relationship revealed that electronic factors in benzothiazole rings had a great effect on the antimicrobial activity of these compounds. The analgesic activity of compounds performed by using tail immersion method. in this case, compound BT-02 shows activity at 100 mg/kg dose 46 ± 0.22, 51 ± 0.22,58 ± 0.43, 48 ± 0.27 at time interval of 30 min,1 hour,2 hour,3 hour respectively compare with the other compounds due to the greater electronic effects.

Keywords


Benzthiazole, Anti Microbial Activity, Tail Immersion Method.