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Acute Toxicity Study of Aqueous Extract of Coccinia indica (Roots)


Affiliations
1 Department of Pharmacognosy, RKDF College of Pharmacy, Bhopal (M.P.), India
2 Department of Pharmacognosy, Lakshminarain College of Pharmacy, Bhopal (M.P.), India
     

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The Present Study was planned to assess the acute toxicity of Coccinia indica roots. Rats were orally administrated single dose of 100, 500 and 1000mg/kg of aqueous extract of Coccinia indica. Mortality, signs of toxicity, body weight, food consumption and gross findings were observed for 07 days post treatment of Coccinia indica extract. In addition, no significant differences were noticed in the body and organ weights between the control and treated groups. These results state that aqueous extract of Coccinia indica is toxicologically safe by oral administration.

Keywords

Acute Toxicity, Coccinia Indica, Roots.
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  • Acute Toxicity Study of Aqueous Extract of Coccinia indica (Roots)

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Authors

Sourabh S. Baghel
Department of Pharmacognosy, RKDF College of Pharmacy, Bhopal (M.P.), India
Sonal Dangi
Department of Pharmacognosy, RKDF College of Pharmacy, Bhopal (M.P.), India
Prashant Soni
Department of Pharmacognosy, RKDF College of Pharmacy, Bhopal (M.P.), India
Priya Singh
Department of Pharmacognosy, Lakshminarain College of Pharmacy, Bhopal (M.P.), India
Yogesh Shivhare
Department of Pharmacognosy, RKDF College of Pharmacy, Bhopal (M.P.), India

Abstract


The Present Study was planned to assess the acute toxicity of Coccinia indica roots. Rats were orally administrated single dose of 100, 500 and 1000mg/kg of aqueous extract of Coccinia indica. Mortality, signs of toxicity, body weight, food consumption and gross findings were observed for 07 days post treatment of Coccinia indica extract. In addition, no significant differences were noticed in the body and organ weights between the control and treated groups. These results state that aqueous extract of Coccinia indica is toxicologically safe by oral administration.

Keywords


Acute Toxicity, Coccinia Indica, Roots.