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Centrally Acting Analgesic Activity and CNS Depressant Activity of Cajanus cajan Linn


Affiliations
1 Department of Pharmacology, Appasaheb Birnale College of Pharmacy, South Shivaji Nagar, Sangli, India
2 Department of Pharmaceutical chemistry, Rajarambapu College of Pharmacy, Kasegaon, Sangli, India
3 Department of Botany, Dr. Patangrao Kadam Mahavidyalya, Sangli, Maharashtra, India
     

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Cajanus cajan Linn which is synonymous to cajanus indicus is given different names like Red Gram. Pigeon Pea, Congo Pea and "Tur" by the local people of India.

The plant is an erect shrub which grows height of 1.5 to 3 meters with many branches. The leaves are pinnately trifoliate and the leaflets are oblong-lanceolate and entire.

The analgesic potency of aqueous extract of the leaves of Cajanus cajan Linn.and CNS depressant activity was investigated using animal model. Result showed that aq. extract of Cajanus cajan Linn. increased pain threshold in mice using hot plate methods and CNS depressant activity in mice by using actophotometer model. It is concluded that the Aqueous extract of Cajanus cajan Linn. can demonstrate strong analgesic and CNS depressant potency comparable in a times and dose dependant manner to a non steroidal anti-inflammatory drugs and benzodiazepines drug respectively.


Keywords

Cajanus cajan Linn, Analgesic Activity, CNS Depressant Activity.
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  • Centrally Acting Analgesic Activity and CNS Depressant Activity of Cajanus cajan Linn

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Authors

Sandeep B. Patil
Department of Pharmacology, Appasaheb Birnale College of Pharmacy, South Shivaji Nagar, Sangli, India
Nilofar S. Naikwade
Department of Pharmacology, Appasaheb Birnale College of Pharmacy, South Shivaji Nagar, Sangli, India
Chandrakant S. Magdum
Department of Pharmaceutical chemistry, Rajarambapu College of Pharmacy, Kasegaon, Sangli, India
Vikas B. Awale
Department of Botany, Dr. Patangrao Kadam Mahavidyalya, Sangli, Maharashtra, India

Abstract


Cajanus cajan Linn which is synonymous to cajanus indicus is given different names like Red Gram. Pigeon Pea, Congo Pea and "Tur" by the local people of India.

The plant is an erect shrub which grows height of 1.5 to 3 meters with many branches. The leaves are pinnately trifoliate and the leaflets are oblong-lanceolate and entire.

The analgesic potency of aqueous extract of the leaves of Cajanus cajan Linn.and CNS depressant activity was investigated using animal model. Result showed that aq. extract of Cajanus cajan Linn. increased pain threshold in mice using hot plate methods and CNS depressant activity in mice by using actophotometer model. It is concluded that the Aqueous extract of Cajanus cajan Linn. can demonstrate strong analgesic and CNS depressant potency comparable in a times and dose dependant manner to a non steroidal anti-inflammatory drugs and benzodiazepines drug respectively.


Keywords


Cajanus cajan Linn, Analgesic Activity, CNS Depressant Activity.