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Wound Healing Activity of Bauhinia purpurea in Albino Wistar Rats


Affiliations
1 Venkateshwara Institute of Pharmaceutical Sciences, Nalgonda, Andhra Pradesh-508001, India
2 GBN Institute of Pharmacy, Ghatkeshar, RR District, Andhra Pradesh-501301, India
3 Saipranavi College of Pharmacy, Keesara, RR district Andhra Pradesh-501301, India
4 Shanta College of Pharmacy, Huzurabad, Karimnagar, Andhra Pradesh-505884, India
5 Anurag College of Pharmacy, Kodada, Nalgonda, Andhra Pradesh-501301, India
     

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The entire wound healing process is a complex series of events that begins at the moment of injury and can continue for months to years. The stages of wound healing are inflammatory phase, proliferation phase, fibroblastic phase and maturation phase. The objective of our study is to investigate wound healing activity of the methanolic leaf extract of of Bauhinia purpurea Linn in rats.. The leaf extract of Bauhinia purpurea (200 mg/kg/day) was evaluated for its wound healing activity in albino rats using excision and incision wound models. Bauhinia purpurea leaf extract treated animals exhibit 83.42 % reduction in wound area when compared to controls which was 76.22 %. The extract treated wounds are found to epithelize faster as compared to controls. Significant (p<0.001) increase in granuloma breaking strength (485±34.64) was observed. The povidone iodine ointment was used as standard.

Keywords

Bauhinia purpurea, Wound Healing, Excision Wound, Incision Wound, Povidone Iodine.
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  • Wound Healing Activity of Bauhinia purpurea in Albino Wistar Rats

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Authors

K. Vijayabhaskar
Venkateshwara Institute of Pharmaceutical Sciences, Nalgonda, Andhra Pradesh-508001, India
Macharla Sravanprasad
GBN Institute of Pharmacy, Ghatkeshar, RR District, Andhra Pradesh-501301, India
Goli. Venkateshwarlu
Venkateshwara Institute of Pharmaceutical Sciences, Nalgonda, Andhra Pradesh-508001, India
P. Suvarna Devi
Saipranavi College of Pharmacy, Keesara, RR district Andhra Pradesh-501301, India
K. Hemanth Kumar
Shanta College of Pharmacy, Huzurabad, Karimnagar, Andhra Pradesh-505884, India
J. Sunil
Anurag College of Pharmacy, Kodada, Nalgonda, Andhra Pradesh-501301, India

Abstract


The entire wound healing process is a complex series of events that begins at the moment of injury and can continue for months to years. The stages of wound healing are inflammatory phase, proliferation phase, fibroblastic phase and maturation phase. The objective of our study is to investigate wound healing activity of the methanolic leaf extract of of Bauhinia purpurea Linn in rats.. The leaf extract of Bauhinia purpurea (200 mg/kg/day) was evaluated for its wound healing activity in albino rats using excision and incision wound models. Bauhinia purpurea leaf extract treated animals exhibit 83.42 % reduction in wound area when compared to controls which was 76.22 %. The extract treated wounds are found to epithelize faster as compared to controls. Significant (p<0.001) increase in granuloma breaking strength (485±34.64) was observed. The povidone iodine ointment was used as standard.

Keywords


Bauhinia purpurea, Wound Healing, Excision Wound, Incision Wound, Povidone Iodine.