Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Tylophora asthmatica L. Prevents Lipid Peroxidation in Acetaminophen Induced Hepato Toxicity in Rats


Affiliations
1 Department of Biotechnology, Bharathidasan University College (w), Orathanadu, Thanjavur, Tamilnadu, India
2 Department of Botany, Jamal Mohamed College, Trichy, Tamilnadu, India
3 Department of Microbiology, Meenakshi Chandrasekaran College of Arts and Science, Pattukkottai – 614 626, Thanjavur, Tamilnadu, India
     

   Subscribe/Renew Journal


Methanolic extract of Tylophora asthmatica leaves were prepared and tested for its antilipidperoxidation effect against acetaminophen induced hepato toxicity in rats. Alteration in the levels of lipid peroxide, iron, ferritin, total cholesterol, total lipid and phospholipids were tested in both experiment and control group of rats. Acetaminophen [1gm/kg] has showed a significant increase [p<0.05] in experimental rats except the level of phospholipids, which showed a significant decrease [p<0.05] compared to control rats. Treatment with methanolic extract of Tylophora asthmatica leaves [200mg/kg] has brought back the altered levels of this parameter to the near normal levels in the dose dependent manner.

Keywords

Acetaminophen, Hepatoprotective, Tylophora asthmatica.
Subscription Login to verify subscription
User
Notifications
Font Size


Abstract Views: 103

PDF Views: 0




  • Tylophora asthmatica L. Prevents Lipid Peroxidation in Acetaminophen Induced Hepato Toxicity in Rats

Abstract Views: 103  |  PDF Views: 0

Authors

R. Malathi
Department of Biotechnology, Bharathidasan University College (w), Orathanadu, Thanjavur, Tamilnadu, India
S. Ahamed John
Department of Botany, Jamal Mohamed College, Trichy, Tamilnadu, India
A. Cholarajan
Department of Microbiology, Meenakshi Chandrasekaran College of Arts and Science, Pattukkottai – 614 626, Thanjavur, Tamilnadu, India

Abstract


Methanolic extract of Tylophora asthmatica leaves were prepared and tested for its antilipidperoxidation effect against acetaminophen induced hepato toxicity in rats. Alteration in the levels of lipid peroxide, iron, ferritin, total cholesterol, total lipid and phospholipids were tested in both experiment and control group of rats. Acetaminophen [1gm/kg] has showed a significant increase [p<0.05] in experimental rats except the level of phospholipids, which showed a significant decrease [p<0.05] compared to control rats. Treatment with methanolic extract of Tylophora asthmatica leaves [200mg/kg] has brought back the altered levels of this parameter to the near normal levels in the dose dependent manner.

Keywords


Acetaminophen, Hepatoprotective, Tylophora asthmatica.