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Mecaptooxadiazole a Lead Molecule in the Medicinal Chemistry: A Review


Affiliations
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni, MS -413736, India
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Nashik, M.S, India
3 Department of Pharmaceutical Chemistry, S.N.D. College of Pharmacy, Yeola, Dist-Nashik, MS, India
4 Department of Pharmaceutical Sciences and Research, Bhagwant University, Ajmer, Rajasthan, India
     

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Mercaptooxadiazole is a five membered heterocyclic system consists of two nitrogen and one oxygen atoms along with acidic thiol group. As it increases the acidity of the titled compounds. It can be easily synthesized from hydazides using potassium hydroxide in presence of carbon disulphide. Mercaptooxadiazoles posses wide spectrum of biological activities like antibacterial, antifungal, antiviral, anti-inflammatory, anticonvulsant, antidepressant, antihypertensive, analgesic, and hypoglycemic properties. The present review is an attempt made to reveal the therapeutic and synthetic profiles of the mercaptooxadiazole ring.

Keywords

Mercaptooxadiazole, Synthesis, Biological Evaluation.
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  • Mecaptooxadiazole a Lead Molecule in the Medicinal Chemistry: A Review

Abstract Views: 69  |  PDF Views: 0

Authors

Nachiket S. Dighe
Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni, MS -413736, India
Ravindra B. Saudagar
Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Nashik, M.S, India
Ramesh S. Kalkotwar
Department of Pharmaceutical Chemistry, S.N.D. College of Pharmacy, Yeola, Dist-Nashik, MS, India
D. A. Jain
Department of Pharmaceutical Sciences and Research, Bhagwant University, Ajmer, Rajasthan, India

Abstract


Mercaptooxadiazole is a five membered heterocyclic system consists of two nitrogen and one oxygen atoms along with acidic thiol group. As it increases the acidity of the titled compounds. It can be easily synthesized from hydazides using potassium hydroxide in presence of carbon disulphide. Mercaptooxadiazoles posses wide spectrum of biological activities like antibacterial, antifungal, antiviral, anti-inflammatory, anticonvulsant, antidepressant, antihypertensive, analgesic, and hypoglycemic properties. The present review is an attempt made to reveal the therapeutic and synthetic profiles of the mercaptooxadiazole ring.

Keywords


Mercaptooxadiazole, Synthesis, Biological Evaluation.