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Formulation and Evaluation of Fast Dissolving Tablet of Drug Used In the Treatment of Motion Sickness


Affiliations
1 Department of Pharmaceutics, Agnihotri College of Pharmacy, Wardha, Maharashtra, India
     

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Fast dissolving tablets are those that dissolve or disintegrate quickly in the oral cavity, resulting in solution or suspension. In the present study Fast dissolving tablet of Scopolamine Hydrobromide was prepared by direct compression method using Indion 414, Cross Carmellose Sodium and sodium starch glycolate as superdisintegrants. The tablets prepared was evaluated for various parameters like various density parameters, thickness, hardness, friability, disintegration time, wetting time and in-vitro dissolution time. All the parameters were found to be within limits. Indion 414 as superdisintegrant gives better result as compared to crosscarmellose sodium and Sodium starch glycolate. Tablets disintegrate within 30 sec in mouth having better mouth feel. The developed formulation of Scopolamine Hydrobromide batch F5 (10% Indion 414) showed good palatability and dispersed within 30 seconds as compared to Cross Carmellose Sodium and Sodium starch glycolate.

Keywords

Fast Dissolving Tablets, Scopolamine Hydrobromide, Indion 414, Superdisintegrant, Palatability.
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  • Formulation and Evaluation of Fast Dissolving Tablet of Drug Used In the Treatment of Motion Sickness

Abstract Views: 42  |  PDF Views: 2

Authors

Satish Shinde
Department of Pharmaceutics, Agnihotri College of Pharmacy, Wardha, Maharashtra, India
Dharmendra Mundhada
Department of Pharmaceutics, Agnihotri College of Pharmacy, Wardha, Maharashtra, India
Rajesh Mujoriya
Department of Pharmaceutics, Agnihotri College of Pharmacy, Wardha, Maharashtra, India

Abstract


Fast dissolving tablets are those that dissolve or disintegrate quickly in the oral cavity, resulting in solution or suspension. In the present study Fast dissolving tablet of Scopolamine Hydrobromide was prepared by direct compression method using Indion 414, Cross Carmellose Sodium and sodium starch glycolate as superdisintegrants. The tablets prepared was evaluated for various parameters like various density parameters, thickness, hardness, friability, disintegration time, wetting time and in-vitro dissolution time. All the parameters were found to be within limits. Indion 414 as superdisintegrant gives better result as compared to crosscarmellose sodium and Sodium starch glycolate. Tablets disintegrate within 30 sec in mouth having better mouth feel. The developed formulation of Scopolamine Hydrobromide batch F5 (10% Indion 414) showed good palatability and dispersed within 30 seconds as compared to Cross Carmellose Sodium and Sodium starch glycolate.

Keywords


Fast Dissolving Tablets, Scopolamine Hydrobromide, Indion 414, Superdisintegrant, Palatability.