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In-Vivo Anti-Inflammatory and Analgesic Screening of Ficus bengalensis Leaf Extract in Rats


Affiliations
1 Dept. of Veterinary Pharmacology and Toxicology, Veterinary College, Bangalore-560024, India
2 Dept. of Veterinary Pathology, Veterinary College, Bangalore-560024, India
3 Dept. of Veterinary Physiology, Veterinary College, Bangalore-560024, India
     

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The present study was conducted to evaluate the analgesic and anti-inflammatory activities of Ficus bengalensis leaf extract in rats using Eddy's hot plate method and formalin induced paw oedema model, respectively. The Ficus benghalensis methanolic leaf extract tested for anti-inflammatory activity, showed a significant (P<0.001) paw volume reduction at dose of 200 mg/kg and at 3 hours. The percent inhibition in paw volume was 65.21% at 200 mg/kg as compared to 62.31% of Diclofenac indicating the anti-inflammatory activity, in formalin-induced paw-edema model. The Ficus benghalensis leaf extract also demonstrated a significant (P<0.001) analgesic activity at both 100 and 200 mg/kg. Thus it can be concluded that the Ficus benghalensis leaf extract possess a potent analgesic and antiinflammatory activities as reflected by the parameters investigated, and demands further research to characterize the novel candidate.

Keywords

Analgesic, Anti-Inflammatory, Ficus Bengalensis Leaf Extract, Eddy’s Hot Plate Method and Formalin Induced Paw Oedema Model.
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  • In-Vivo Anti-Inflammatory and Analgesic Screening of Ficus bengalensis Leaf Extract in Rats

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Authors

Prathap Kumar Kothapalli
Dept. of Veterinary Pharmacology and Toxicology, Veterinary College, Bangalore-560024, India
S. Jagadeesh Sanganal
Dept. of Veterinary Pharmacology and Toxicology, Veterinary College, Bangalore-560024, India
N. B. Shridhar
Dept. of Veterinary Pharmacology and Toxicology, Veterinary College, Bangalore-560024, India
H. D. Narayanaswamy
Dept. of Veterinary Pathology, Veterinary College, Bangalore-560024, India
M. Narayanaswamy
Dept. of Veterinary Physiology, Veterinary College, Bangalore-560024, India

Abstract


The present study was conducted to evaluate the analgesic and anti-inflammatory activities of Ficus bengalensis leaf extract in rats using Eddy's hot plate method and formalin induced paw oedema model, respectively. The Ficus benghalensis methanolic leaf extract tested for anti-inflammatory activity, showed a significant (P<0.001) paw volume reduction at dose of 200 mg/kg and at 3 hours. The percent inhibition in paw volume was 65.21% at 200 mg/kg as compared to 62.31% of Diclofenac indicating the anti-inflammatory activity, in formalin-induced paw-edema model. The Ficus benghalensis leaf extract also demonstrated a significant (P<0.001) analgesic activity at both 100 and 200 mg/kg. Thus it can be concluded that the Ficus benghalensis leaf extract possess a potent analgesic and antiinflammatory activities as reflected by the parameters investigated, and demands further research to characterize the novel candidate.

Keywords


Analgesic, Anti-Inflammatory, Ficus Bengalensis Leaf Extract, Eddy’s Hot Plate Method and Formalin Induced Paw Oedema Model.