Asian Journal of Research in Pharmaceutical Sciences

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Development and Validation of RP-HPLC for Simultaneous Estimation of Cefpodoxime Proxetil and Dicloxacillin Sodium Tablets


Affiliations
1 Department of Pharmaceutical Analysis and QA, Teegala Ramreddy College of Pharmacy, Meerpet, Hyderabad-500097, Telangana, India
2 Pharmaceutical Analysis, Jawaharlal Nehru Technological University Kakinada, Kakinada- 533003. A.P., India
3 Chilkur Balaji College of Pharmacy, Aziz Nagar, Hyderabad, Telangana, India
     

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The present work deals with the development of a precise, accurate, simple, specific, reliable and less time consuming RP-HPLC method for the estimation of Cefpodoxime Proxetil and Dicloxacillin Sodium tablets. The chromatographic separation was achieved on a Inertsil C18 ODS (4.6 x 250mm, 5μm) with a mobile phase combination of methanol and water (50:50) v/v at a flow rate of 1.0 ml/min, and the detection was carried out by using PDA detector at 290 nm. Ambient column temperature has maintained. The total run time was 10 mins.The retention time of Dicloxacillin Sodium and Cefpodoxime Proxetil were found to be 2.9 min. and 3.5 min. respectively. The performance of the method was validated according to the present ICH guidelines.

Keywords

RP-HPLC, Cefpodoxime Proxetil, Dicloxacillin Sodium, Tablet Dosage Forms, RP-HPLC Method.
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  • Development and Validation of RP-HPLC for Simultaneous Estimation of Cefpodoxime Proxetil and Dicloxacillin Sodium Tablets

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Authors

M. A. Zeeshan Hamza
Department of Pharmaceutical Analysis and QA, Teegala Ramreddy College of Pharmacy, Meerpet, Hyderabad-500097, Telangana, India
G. Kumaraswamy
Pharmaceutical Analysis, Jawaharlal Nehru Technological University Kakinada, Kakinada- 533003. A.P., India
Gandla Lalitha
Chilkur Balaji College of Pharmacy, Aziz Nagar, Hyderabad, Telangana, India
R. Suthakaran
Department of Pharmaceutical Analysis and QA, Teegala Ramreddy College of Pharmacy, Meerpet, Hyderabad-500097, Telangana, India

Abstract


The present work deals with the development of a precise, accurate, simple, specific, reliable and less time consuming RP-HPLC method for the estimation of Cefpodoxime Proxetil and Dicloxacillin Sodium tablets. The chromatographic separation was achieved on a Inertsil C18 ODS (4.6 x 250mm, 5μm) with a mobile phase combination of methanol and water (50:50) v/v at a flow rate of 1.0 ml/min, and the detection was carried out by using PDA detector at 290 nm. Ambient column temperature has maintained. The total run time was 10 mins.The retention time of Dicloxacillin Sodium and Cefpodoxime Proxetil were found to be 2.9 min. and 3.5 min. respectively. The performance of the method was validated according to the present ICH guidelines.

Keywords


RP-HPLC, Cefpodoxime Proxetil, Dicloxacillin Sodium, Tablet Dosage Forms, RP-HPLC Method.