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Pharmaceutical Co-Crystallization


Affiliations
1 Department of Pharmaceutics, KCT'S R.G. Sapkal College of Pharmacy, Anjenari, Dist. Nashik-422212, Maharashtra, India
2 Department of Pharmaceutical Chemistry, KCT'S R.G. Sapkal College of Pharmacy, Anjenari, Dist. Nashik-422212, Maharashtra, India
     

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Co-crystal consists of API and a stoichiometric amount of a pharmaceutically acceptable co-crystal former. Pharmaceutical Co-crystal is non-ionic supramolecular complexes and can be used to address physical property issues such as solubility, stability and bioavailability in pharmaceutical development without changing the chemical composition of the API. Co-crystal is a crystalline entity formed by two different or more molecular entities where the intermolecular interactions are weak forces like hydrogen bonding and π-π stacking. Super porous systems, biodegradable hydrogel systems. Co crystallization alters the molecular interaction and composition of pharmaceutical materials, and is considered better alternative to optimize drug properties. The article gives brief review on the co-crystallization, selection of appropriate co former and preparation of co crystals, different techniques of co-crystallization, physicochemical properties, characterization and applications.

Keywords

Pharmaceutical Co-Crystal, Method of Preparation, Characterization of Co-Crystal, and Applications.
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  • Pharmaceutical Co-Crystallization

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Authors

Swapnil R. Lahamage
Department of Pharmaceutics, KCT'S R.G. Sapkal College of Pharmacy, Anjenari, Dist. Nashik-422212, Maharashtra, India
Avinash B. Darekar
Department of Pharmaceutics, KCT'S R.G. Sapkal College of Pharmacy, Anjenari, Dist. Nashik-422212, Maharashtra, India
Ravindra B. Saudagar
Department of Pharmaceutical Chemistry, KCT'S R.G. Sapkal College of Pharmacy, Anjenari, Dist. Nashik-422212, Maharashtra, India

Abstract


Co-crystal consists of API and a stoichiometric amount of a pharmaceutically acceptable co-crystal former. Pharmaceutical Co-crystal is non-ionic supramolecular complexes and can be used to address physical property issues such as solubility, stability and bioavailability in pharmaceutical development without changing the chemical composition of the API. Co-crystal is a crystalline entity formed by two different or more molecular entities where the intermolecular interactions are weak forces like hydrogen bonding and π-π stacking. Super porous systems, biodegradable hydrogel systems. Co crystallization alters the molecular interaction and composition of pharmaceutical materials, and is considered better alternative to optimize drug properties. The article gives brief review on the co-crystallization, selection of appropriate co former and preparation of co crystals, different techniques of co-crystallization, physicochemical properties, characterization and applications.

Keywords


Pharmaceutical Co-Crystal, Method of Preparation, Characterization of Co-Crystal, and Applications.