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Evaluation of Diuretic Potential of Amritarishta Prepared by Traditional and Modern Methods in Experimental Albino Rats


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1 Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar, Uttar Pradesh, India
     

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The objective of the present study was to evaluate the diuretic potential of Amritarishta-T and Amritarishta-M prepared by traditional and modern methods respectively and its marketed formulation in experimental rats using furosemide (10 mg/kg p.o.) as a standard diuretic drug. Oral administration of Amritarishta-T, Amritarishta-M and its marketed formulation at the dose of 2.0 ml/kg over a period of 5 h showed a significant increase in urine volume as compared to control group. Both types of Amritarishta as Amritarishta-T and Amritarishta-M prepared by traditional and modern methods respectively and its marketed formulation showed significant increase in sodium, potassium and chloride level in urine sample as compared to control group. The maximum diuretic effect was produced by furosemide. Thus, both types of Amritarishta as Amritarishta-T and Amritarishta-M and its marketed formulation showed significant diuretic, natriuretic and kaliuretic effects.

Keywords

Diuretic Potential, Furosemide, Amritarishta, Natriuretic Effect, Kaliuretic Effect.
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  • Evaluation of Diuretic Potential of Amritarishta Prepared by Traditional and Modern Methods in Experimental Albino Rats

Abstract Views: 14  |  PDF Views: 1

Authors

Preeti Tiwari
Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar, Uttar Pradesh, India

Abstract


The objective of the present study was to evaluate the diuretic potential of Amritarishta-T and Amritarishta-M prepared by traditional and modern methods respectively and its marketed formulation in experimental rats using furosemide (10 mg/kg p.o.) as a standard diuretic drug. Oral administration of Amritarishta-T, Amritarishta-M and its marketed formulation at the dose of 2.0 ml/kg over a period of 5 h showed a significant increase in urine volume as compared to control group. Both types of Amritarishta as Amritarishta-T and Amritarishta-M prepared by traditional and modern methods respectively and its marketed formulation showed significant increase in sodium, potassium and chloride level in urine sample as compared to control group. The maximum diuretic effect was produced by furosemide. Thus, both types of Amritarishta as Amritarishta-T and Amritarishta-M and its marketed formulation showed significant diuretic, natriuretic and kaliuretic effects.

Keywords


Diuretic Potential, Furosemide, Amritarishta, Natriuretic Effect, Kaliuretic Effect.