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Pleiotropic Effects of Statins


Affiliations
1 College of Pharmacy (D.Pharm) Degaon, Satara, (MH)- 415 004, India
2 College of Pharmacy (D.Pharm) Degaon, Satara, (MH) - 415 004, India
     

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Statins are the most commonly prescribed drugs worldwide, are cholesterol lowering agents used to manage and prevent cardiovascular and coronary heart diseases. Recently a multifaceted actions in different physiological and pathological conditions has been also proposed for statins such as antiiflammation, neuroprotection etc. Statins have been shown to act through cholesterol dependant & independent mechanisms which are able to affect several tissue functions and modulate specific signal transduction pathways. Here we review the pharmacology of statins, providing a comprehensive update of the current knowledge of their effects on tissues, biological processes & pathological conditions; but statins are now becoming recognized as powerful anti-inflammatory agents that exert beneficial effects beyond low density lipoprotein cholesterol reduction.
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  • Pleiotropic Effects of Statins

Abstract Views: 56  |  PDF Views: 2

Authors

Puja S. Gaikwad
College of Pharmacy (D.Pharm) Degaon, Satara, (MH)- 415 004, India
Dhanshri U. Gadhave
College of Pharmacy (D.Pharm) Degaon, Satara, (MH)- 415 004, India
Nayna V. Pimpodkar
College of Pharmacy (D.Pharm) Degaon, Satara, (MH) - 415 004, India
Trushali A. Mandhare
College of Pharmacy (D.Pharm) Degaon, Satara, (MH) - 415 004, India

Abstract


Statins are the most commonly prescribed drugs worldwide, are cholesterol lowering agents used to manage and prevent cardiovascular and coronary heart diseases. Recently a multifaceted actions in different physiological and pathological conditions has been also proposed for statins such as antiiflammation, neuroprotection etc. Statins have been shown to act through cholesterol dependant & independent mechanisms which are able to affect several tissue functions and modulate specific signal transduction pathways. Here we review the pharmacology of statins, providing a comprehensive update of the current knowledge of their effects on tissues, biological processes & pathological conditions; but statins are now becoming recognized as powerful anti-inflammatory agents that exert beneficial effects beyond low density lipoprotein cholesterol reduction.