Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Review on Resealed Erythrocyte


Affiliations
1 Department of Quality Assurance Technique, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, India
     

   Subscribe/Renew Journal


Erythrocytes, also known as red blood cells, and have been extensively studied for their potential carrier capabilities for the delivery of drugs. Such drug-loaded carrier erythrocytes are prepared simply by collecting blood samples from the organism of interest, separating erythrocytes from plasma, entrapping drug in the erythrocytes, and resealing the resultant cellular carriers, these carriers are called resealed erythrocytes. Among the various carriers used for targeting drugs to various body tissues, the cellular carriers meet several criteria desirable in clinical applications, among the most important being biocompatibility of carrier and its degradation products. Carrier erythrocytes, resealed erythrocytes loaded by a drug or other therapeutic agents, have been exploited extensively in recent years for both temporally and spatially controlled delivery of a wide variety of drugs and other bioactive agents owing to their remarkable degree of biocompatibility, biodegradability and a series of other potential advantages. Leucocytes, platelets, erythrocytes, nano erythrocytes, hepatocytes, and fibroblast etc. have been proposed as cellular carrier systems. Among these, the erythrocytes have been the most investigated and have found to possess greater potential in drug delivery. In this review article, the potential applications of erythrocytes in drug delivery have been reviewed with a particular stress on the studies and laboratory experiences on successful erythrocyte loading and characterization of the different classes of biopharmaceuticals.

Keywords

Resealed Erythrocytes, Drug Targeting, Isolation, Drug Loading Method, Characterization Methods and Applications.
Subscription Login to verify subscription
User
Notifications
Font Size


Abstract Views: 49

PDF Views: 0




  • Review on Resealed Erythrocyte

Abstract Views: 49  |  PDF Views: 0

Authors

Sarika V. Khandbahale
Department of Quality Assurance Technique, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, India
R. B. Saudagar
Department of Quality Assurance Technique, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, India

Abstract


Erythrocytes, also known as red blood cells, and have been extensively studied for their potential carrier capabilities for the delivery of drugs. Such drug-loaded carrier erythrocytes are prepared simply by collecting blood samples from the organism of interest, separating erythrocytes from plasma, entrapping drug in the erythrocytes, and resealing the resultant cellular carriers, these carriers are called resealed erythrocytes. Among the various carriers used for targeting drugs to various body tissues, the cellular carriers meet several criteria desirable in clinical applications, among the most important being biocompatibility of carrier and its degradation products. Carrier erythrocytes, resealed erythrocytes loaded by a drug or other therapeutic agents, have been exploited extensively in recent years for both temporally and spatially controlled delivery of a wide variety of drugs and other bioactive agents owing to their remarkable degree of biocompatibility, biodegradability and a series of other potential advantages. Leucocytes, platelets, erythrocytes, nano erythrocytes, hepatocytes, and fibroblast etc. have been proposed as cellular carrier systems. Among these, the erythrocytes have been the most investigated and have found to possess greater potential in drug delivery. In this review article, the potential applications of erythrocytes in drug delivery have been reviewed with a particular stress on the studies and laboratory experiences on successful erythrocyte loading and characterization of the different classes of biopharmaceuticals.

Keywords


Resealed Erythrocytes, Drug Targeting, Isolation, Drug Loading Method, Characterization Methods and Applications.