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Prabhakar, Virupakshi
- Design, Synthesis, Structural Elucidation and Antimicrobial Screening of Novel 1, 5-Benzothiazepine Derivatives Derived from Thieno [3, 2-d] Pyrimidine Nucleus
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Authors
Virupakshi Prabhakar
1,
Kondra Sudhakar Babu
2,
L. K. Ravindranath
2,
J. Latha
3,
B. Venkateswarlu
4
Affiliations
1 SVR Engineering College, Jawaharlal Nehru Technological University-Ananthapuramu (JNTU-A), Nandyal, Pin 518502, Kurnool (Dist), A.P., IN
2 Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, (A P), IN
3 Department of Environmental Science, Sri Krishnadevaraya University College of Engineering and Technology, S. K. University, Ananthapuramu – 515003 (A.P), IN
4 PBR VITS, Jawaharlal Nehru Technological University (JNTU-A), Kavali, Nellore (Dist), (A.P.), IN
1 SVR Engineering College, Jawaharlal Nehru Technological University-Ananthapuramu (JNTU-A), Nandyal, Pin 518502, Kurnool (Dist), A.P., IN
2 Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, (A P), IN
3 Department of Environmental Science, Sri Krishnadevaraya University College of Engineering and Technology, S. K. University, Ananthapuramu – 515003 (A.P), IN
4 PBR VITS, Jawaharlal Nehru Technological University (JNTU-A), Kavali, Nellore (Dist), (A.P.), IN
Source
Asian Journal of Research in Chemistry, Vol 10, No 1 (2017), Pagination: 58-68Abstract
1, 5-Benzo Thiazepine is the Main Seven membered Heterocyclic ring systems reported for their cardiac and Psychotherapeutic activities.1,5 Benzo Thiazepines were highlighted as important Biologically active Scaffolds. In This Article New series of benzo [b] [1, 5]-thiazepine derivatives 6 a-j were synthesized by applying the cyclo condensation of (E)-3-(thieno [3, 2-d] pyrimidin-6-yl)-1-p-Substituted prop-2-en-1-one derivatives 4a-j with 2-amino thio phenol (5) in DMF. The new intermediate Chalcone derivatives 4a-j were obtained from interaction of various P-substituted Acetophenone&Heterocyclic Acetyl derivatives 3(a-j) and thieno[3,2-d]pyrimidine-7-carbaldehyde. The synthesized 1, 5-benzothiazepines 6a-j have been screened for their antimicrobial activity. From anti-bacterial and anti-fungal activity screening results, it has been observed that compounds 6h, 6e, 6i and 6d possess good activity.Keywords
Chalcones, 2-Amino Thio Phenol, Cyclisation, 1, 5-Benzothiazepines, Anti-Microbial Activity, Thieno [3, 2-d] Pyrimidine Core Ring.
References
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- Design, Synthesis and Activity of Novel Quinazoline Derivatives Linked with Various Sulphonamides
Abstract Views :204 |
PDF Views:2
Authors
Affiliations
1 SVR Engineering College, Jawaharlal Nehru Technological University (JNTU-A), Nandyal, Kurnool (Dist), A.P., 518502, IN
2 PBR VITS, Jawaharlal Nehru Technological University (JNTU-A), Kavali, Nellore (Dist), (A.P.), IN
3 Prajna Solutions Pvt. Ltd., Hyderabad, Telangana, IN
1 SVR Engineering College, Jawaharlal Nehru Technological University (JNTU-A), Nandyal, Kurnool (Dist), A.P., 518502, IN
2 PBR VITS, Jawaharlal Nehru Technological University (JNTU-A), Kavali, Nellore (Dist), (A.P.), IN
3 Prajna Solutions Pvt. Ltd., Hyderabad, Telangana, IN
Source
Asian Journal of Research in Chemistry, Vol 9, No 10 (2016), Pagination: 485-504Abstract
Quinazoline nucleus is present in various compounds and it is responsible for diverse biological activities. The present work mainly focused on the Quinazolines with potential activities that are now in development. The objective of this research work is to synthesize various compounds containing Quinazoline moiety and their derivatives as well as characterising the compounds by spectral analysis and screening for antimicrobial and anticancer activities. The structures of synthesized compounds were confirmed by various spectroscopic methods such as IR, NMR and mass spectroscopy. The products were evaluated for their antimicrobial activity against several microbes. Some of the compounds exhibited potent anti-bacterial activity as well as anti-fungal activity. Among the Novel Quinazoline derivatives 8i, 8j, 8d shows Excellent Anti-microbial activity.Keywords
Quinazolines, Thiomorpholine, Sulphonamides, Cyclisation, Anti-Microbial Screening.- Synthesis and Biological Activities of Novel Thieno[3, 2-d] Pyrimidine Derivatives
Abstract Views :616 |
PDF Views:7
Authors
Affiliations
1 SVR Engineering College, Jawaharlal Nehru Technological University-Ananthapuramu (Jntu-A), Nandyal, Kurnool (Dist), A.P., IN
2 Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, (AP), IN
3 PBR VITS, Jawaharlal Nehru Technological University (Jntu-A), Kavali, Nellore (Dist), (A.P.), IN
1 SVR Engineering College, Jawaharlal Nehru Technological University-Ananthapuramu (Jntu-A), Nandyal, Kurnool (Dist), A.P., IN
2 Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, (AP), IN
3 PBR VITS, Jawaharlal Nehru Technological University (Jntu-A), Kavali, Nellore (Dist), (A.P.), IN
Source
Asian Journal of Research in Chemistry, Vol 10, No 3 (2017), Pagination: 280-290Abstract
A series of novel 4-Substituted/Heterocyclic-N-(4-thiomorpholinothieno[3,2-d]pyrimidin-2-yl)benzamide (8a-j) derivatives were synthesized by a Five-step procedure that afforded advantages of mild reaction conditions, simple protocol and good yields. The structures of the final compounds were confirmed by IR, NMR, EI-MS. The final compounds were screened for their anti-bacterial activity against Staphylococcus aureus (S. aureus) and Bacillus subtilis (B. subtilis)from Gram positive group of bacteria and Pseudomonas aeruginosa (P. aeruginosa) and Escherichia coli (E. coli) from Gram negative group of bacteria and antifungal activity against Aspergillus niger (A. niger) and Candida albicans (C. albicans). Anti-bacterial and anti-fungal activities were Evaluated and compared with the standard drugsSuch asAmoxicillin &Flucanazole From anti-bacterial and antifungal activity screening results, it has been observed that compounds 8j, 8i, 8e and 8f possess good activity.Keywords
Thieno [3, 2-d] Pyrimidine, 2-Chloro-4-Thio Morpholine Thieno[3, 2-d]Pyrimidine Synthesis, Anti-Bacterial, Anti-Fungal Activity, HATU.- Application of Chalcones in Synthesis of Novel 1, 5-Benzodiazepine Derivatives Containing Thieno [2, 3-d] Pyrimidine Core Unit and its Biological Activity Screening
Abstract Views :217 |
PDF Views:6
Authors
Virupakshi Prabhakar
1,
Kondra Sudhakar Babu
2,
L. K. Ravindranath
2,
M. Sahanoor Basha
1,
J. Latha
3
Affiliations
1 SVR Engineering College, Jawaharlal Nehru Technological University-Ananthapuramu (JNTU-A), Nandyal, Pin 518502, Kurnool (Dist), A.P., IN
2 Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, (A P), IN
3 Department of Environmental Science, Sri Krishnadevaraya University College of Engineering and Technology, S.K. University, Ananthapuramu – 515003 (A.P), IN
1 SVR Engineering College, Jawaharlal Nehru Technological University-Ananthapuramu (JNTU-A), Nandyal, Pin 518502, Kurnool (Dist), A.P., IN
2 Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, (A P), IN
3 Department of Environmental Science, Sri Krishnadevaraya University College of Engineering and Technology, S.K. University, Ananthapuramu – 515003 (A.P), IN
Source
Asian Journal of Research in Chemistry, Vol 10, No 2 (2017), Pagination: 71-84Abstract
Di azepines, which were synthesized by different methods shown in literature and also Di azepines are great importance in heterocyclic chemistry and more importance in biology and pharmacology. Di azepines are very biological active molecules. In this work A new series of 1, 5-Benzodizepine derivatives were synthesized from chalcones and evaluated for their Antimicrobial activities. First Chalcones were prepared by treatment of Thieno [2, 3-d] pyrimidine-6-carbaldehyde with different acetophenones by Claisen-Schimidt Condensation. Various Benzodiazepines derivatives were prepared by reaction of Chalcone in DMF with o-phenylene di amine in presence of piperidine. The structures of the newly synthesized Benzodiazepine derivatives have been established on the basis of their spectral data. The synthesized selected compounds were evaluated for their antimicrobial activities.Keywords
Chalcones, O-Phenylene Diamine, [1, 5]-Benzodiazepines, Thieno [2, 3-d] Pyrimidines, Antibacterial Activity, Antifungal Activity.- Synthesis and Biological Activities of Novel Thieno [3, 2-d] Pyrimidine Derivatives
Abstract Views :161 |
PDF Views:4
Authors
Affiliations
1 SVR Engineering College, Jawaharlal Nehru Technological University-Ananthapuramu (JNTU-A), Nandyal, Kurnool (Dist), A.P., IN
2 Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, (A.P.), IN
3 PBR VITS, Jawaharlal Nehru Technological University (JNTU-A), Kavali, Nellore (Dist), (A.P.), IN
1 SVR Engineering College, Jawaharlal Nehru Technological University-Ananthapuramu (JNTU-A), Nandyal, Kurnool (Dist), A.P., IN
2 Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, (A.P.), IN
3 PBR VITS, Jawaharlal Nehru Technological University (JNTU-A), Kavali, Nellore (Dist), (A.P.), IN