Asian Journal of Research in Chemistry

V. Prabhakar ¹, K. Sudhakar Babu ¹, L. K. Ravindranath ¹, P. V. Ramana Reddy ², J. Latha ³

Affiliations
1 Department of Chemistry, Sri Krishnadevaraya University, Anantapuramu, (A P), IN
2 Department of Chemistry, Loyola Degree College, Sri Yogivemana University, Kadapa , (A P), IN
3 Department of Bio-Technology, Sri Krishnadevaraya University College of Engineering and Technology, Anantapuramu – 515003 (A.P), IN

Abstract

A Novel Series of Compounds were synthesized by Condensation reaction of Carbazole aldehyde with Substituted Acetophenone derivatives 4 (a-d) in presence of alcoholic Sodium hydroxide Solution to get Chalcone Intermediates 5 (a-d), which were further treated hydroxyl amine hydrochloride in presence of Pyridine to get Iso Oxazoline Derivatives 6 (a-d). The latter were refluxed with Substituted Primary amines and formaldehyde for 8-10 hrs to get Mannich bases. The Structures of new compounds were confirmed by IR and 1H NMR and 13C NMR Spectral Data. Anti-bacterial and Anti-fungal Activities were evaluated and compared with the standard drugs, some compounds of the series Exhibited Promising Anti-microbial and Anti-fungal Activity Compared to Standard Drugs.

Keywords

Chalcone, Isoxazoline, Carbazoles, Mannich Bases, Anti-Bacterial, Antifungal Activity.

Full Text

     

Virupakshi Prabhakar ¹, K. Sudhakar Babu ², L. K. Ravindranath ², B. Venkateswarlu ³

Affiliations
1 SVR Engineering College, Jawaharlal Nehru Technological University-Ananthapuramu (Jntu-A), Nandyal, Kurnool (Dist), A.P., IN
2 Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, (AP), IN
3 PBR VITS, Jawaharlal Nehru Technological University (Jntu-A), Kavali, Nellore (Dist), (A.P.), IN

Abstract

A series of novel 4-Substituted/Heterocyclic-N-(4-thiomorpholinothieno[3,2-d]pyrimidin-2-yl)benzamide (8a-j) derivatives were synthesized by a Five-step procedure that afforded advantages of mild reaction conditions, simple protocol and good yields. The structures of the final compounds were confirmed by IR, NMR, EI-MS. The final compounds were screened for their anti-bacterial activity against Staphylococcus aureus (S. aureus) and Bacillus subtilis (B. subtilis)from Gram positive group of bacteria and Pseudomonas aeruginosa (P. aeruginosa) and Escherichia coli (E. coli) from Gram negative group of bacteria and antifungal activity against Aspergillus niger (A. niger) and Candida albicans (C. albicans). Anti-bacterial and anti-fungal activities were Evaluated and compared with the standard drugsSuch asAmoxicillin &Flucanazole From anti-bacterial and antifungal activity screening results, it has been observed that compounds 8j, 8i, 8e and 8f possess good activity.

Keywords

Thieno [3, 2-d] Pyrimidine, 2-Chloro-4-Thio Morpholine Thieno[3, 2-d]Pyrimidine Synthesis, Anti-Bacterial, Anti-Fungal Activity, HATU.

Full Text

     

Virupakshi Prabhakar ¹, K. Sudhakar Babu ², L. K. Ravindranath ², B. Venkateswarlu ³

Affiliations
1 SVR Engineering College, Jawaharlal Nehru Technological University-Ananthapuramu (JNTU-A), Nandyal, Kurnool (Dist), A.P., IN
2 Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, (A.P.), IN
3 PBR VITS, Jawaharlal Nehru Technological University (JNTU-A), Kavali, Nellore (Dist), (A.P.), IN

Abstract

A series of novel 4-Substituted/Heterocyclic-N-(4-thiomorpholinothieno[3,2-d]pyrimidin-2-yl)benzamide (8a-j) derivatives were synthesized by a Five-step procedure that afforded advantages of mild reaction conditions, simple protocol and good yields. The structures of the final compounds were confirmed by IR, NMR, EI-MS. The final compounds were screened for their anti-bacterial activity against Staphylococcus aureus (S. aureus) and Bacillus subtilis (B. subtilis) from Gram positive group of bacteria and Pseudomonas aeruginosa (P. aeruginosa) and Escherichia coli (E. coli) from Gram negative group of bacteria and antifungal activity against Aspergillus niger (A. niger) and Candida albicans (C. albicans). Anti-bacterial and anti-fungal activities were Evaluated and compared with the standard drugs Such as Amoxicillin and Flucanazole From anti-bacterial and anti-fungal activity screening results, it has been observed that compounds 8j, 8i, 8e and 8f possess good activity.

Keywords

Thieno [3, 2-d] Pyrimidine, 2-Chloro-4-Thio Morpholine Thieno [3, 2-d]Pyrimidine Synthesis, Anti-Bacterial, Anti-Fungal Activity, HATU.

Full Text