Asian Journal of Research in Chemistry

Kouser Unnisa ¹, Tahseen Sameena ¹, Habeeba Sulthana ¹, Hafsa Siddiqua ¹, Maimunna Khatoon ¹

Affiliations
1 Department of Pharmaceutical Chemistry, Azad College of Pharmacy, Moinabad-Chilkur Road, Hyderabad-500075, IN

Abstract

Natural products derived from plants or microbes play a major role in drug discovery as a source of original bioactive structures and offer models for rational drug design. The promising natural anti-mycobacterials include carbazole alkaloids, such as Clausine and Micromeline isolated independently from several sources and were shown to have potent antitubercular activity. In recent years, carbazole alkaloids are playing important role in discovering new antitubercular leads against non-resistant and multi-drug resistant strains of M. tuberculosis. Few among them are 7-hydroxymukonal (IX, MIC 25lg/mL), Clausine K (MIC: 100lg/mL), and Micromeline (MIC: 31.5lg/mL). Knölker screened a series of carbazole alkaloids for their in vitro anti-TB activity. It appeared that anti-TB activity is highly sensitive to subtle changes in substitution around the carbazole ring system. Herein we report the synthesis of Nine Novel Carbazole linked propeonones in excellent yields via N-Methylation of Carbazole followed by Friedel's crafts acylation of N-methyl carbazole. All the compounds were characterised by Spectroscopic methods.

Keywords

Carbazole Alkaloids, Anti-TB Activity, Carbazole Linked Propeonones and N-Methylation.

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Habeeba Sultana ¹, Tahseen Sameena ¹, Hafsa Siddiqua ¹, Kouser Unnisa ¹

Affiliations
1 Department of Pharmacology, Azad College of Pharmacy, Moinabad-Chilkur Road, Hyderabad-500075, IN

Abstract

Vendu chettu (Rhynchosia beddomei) Whole plant is ascribed with many therapeutic effects. The present study was undertaken to explore the anti-hyperlipidemic effect of four different extracts viz. Methanol, chloroform, alcoholic and aqueous extracts from Vendu chettu in Progesterone and Mono sodium gluconate induced hyperlipidemic rats and their hypolipidemic effects in normocholesteremic rats. The study is comprised preliminary phytochemical screening of the extracts. Oral administration of the extracts, at doses of 100, 200 and 400 mg/kg body weight in rats, dose-dependently inhibited the total cholesterol, triglycerides, low-density lipoproteins level, and significantly increased the high density lipoproteins level. Only methanolic extract exhibited more significant effects in lowering total cholesterol triglycerides and low density lipoproteins along with increase in HDL as compared to the others. Preliminary phytochemical screening revealed the presence of Alkaloids, Anthracene glycosides, Anthraquinones and Caratinoids, Coumarins, Flavonoids, Gallic tannins, Saponins Triterpenoids, Volatile oils are reported in the Leaf extract. The results obtained suggest marked antihyperlipidemic and hypolipidemic activity of the Whole plant extracts.

Keywords

Hypolipidemic, Rhynchosia beddomei, Progesterone, Sibutramine.

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