Asian Journal of Research in Chemistry

Pankaj Gupta ¹, Hardwari Lal Yadav ¹, G. Garg ¹, R. S. Pawar ¹, U. K. Patil ¹, P. K. Singour ¹

Affiliations
1 Department of Pharmaceutical Chemistry, VNS Institute of Pharmacy, Neelbud, Bhopal-462044, M.P, IN

Abstract

A series of 1-(2/4-substituted-benzoyl)-3-benzothiazol-2-yl-thiourea were synthesized from benzothiazol-2-yl-amine and 2/4-substituted benzoylisothiocyanates in satisfactory yields. The newly synthesized compounds were characterized by UV, IR, and ¹H-NMR spectroscopy. The synthesized compounds were evaluated for analgesic activity by hot plate method using aspirin (100 mg/kg) as standard compound. The results highlights that the some compound shows significant analgesic activity.

Keywords

2-Aminobenzothiazole Derivatives, Synthesis, Analgesic Activity.

Full Text

     

Pankaj Gupta ¹, Hardwari Lal Yadav ¹, G. Garg ¹, R. S. Pawar ¹, U. K. Patil ¹, P. K. Singour ¹

Affiliations
1 Department of Pharmaceutical Chemistry, VNS Institute of Pharmacy, Neelbud, Bhopal-462044, M.P, IN

Abstract

A series of 1-(2/4-substituted-benzoyl)-3-benzothiazol-2-yl-thiourea were synthesized from benzothiazol-2-yl-amine and 2/4-substituted benzoylisothiocyanates in satisfactory yields. The newly synthesized compounds were characterized by UV, IR, and ¹H-NMR spectroscopy. The synthesized compounds were evaluated for analgesic activity by hot plate method using aspirin (100 mg/kg) as standard compound. The results highlights that the some compound shows significant analgesic activity.

Keywords

2-Aminobenzothiazole Derivatives, Synthesis, Analgesic Activity.

Full Text