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Singh, Arvind Kumar
- 1, 2, 4- Triazole Derivatives and its Pharmacological Activities
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Authors
Affiliations
1 Kamla Nehru Institute of Management and Technology (Faculty of Pharmacy), Sultanpur UP-228001, IN
1 Kamla Nehru Institute of Management and Technology (Faculty of Pharmacy), Sultanpur UP-228001, IN
Source
Asian Journal of Research in Chemistry, Vol 6, No 5 (2013), Pagination: 429-437Abstract
Triazole, a heterocyclic nucleus has attracted a wide attention of the medicinal chemist in search for the new therapeutic molecules. This review provides a brief summary of 1,2,4-triazole Derivatives and its Pharmacological activities and highlights some examples of 1,2,4-triazole-containing drug substances. Either as single heterocyclic derivatives or in fusion with the other cycles, these heterocycle is emerging as the most explored centre to obtain clinically significant compounds. The major activities exhibited by 1,2,4 derivatives include antibacterial, antifungal, antiviral, antidepressant, antimalarial, hypnotic, anticonvulsant and anti-inflammatory activities.Keywords
1,2,4- Triazoles, Pharmacological Activities
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- Pharmacological Activities of Benzimidazole Derivatives - An Overview
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Authors
Affiliations
1 Kamla Nehru Institute of Management & Technology (Faculty of Pharmacy, Department of Pharmaceutical Chemistry), Faridipur, Sultanpur, Uttar Pradesh, IN
1 Kamla Nehru Institute of Management & Technology (Faculty of Pharmacy, Department of Pharmaceutical Chemistry), Faridipur, Sultanpur, Uttar Pradesh, IN
Source
Asian Journal of Research in Chemistry, Vol 6, No 5 (2013), Pagination: 448-458Abstract
Benzimidazole derivates play vital role in biological field such as antimicrobial, antiviral, antidiabetic, and anticancer activity. Therapeutic Significance of these clinically useful drugs in treatment of microbial infections encouraged the development of some more potent and significant compounds. Benzimidazoles are remarkably effective compounds both with respect to their bacteria inhibitory activity and their favorable selectivity ratio. Extensive biochemical and pharmacological studies have confirmed that these molecules are effective against various strains of microorganisms. This comprehensive overview summarizes the chemistry of different derivatives of substituted benzimidazole along with their antimicrobial activity.Keywords
Substituted Benzimidazoles, Therapeutic Significance, Antimicrobial ActivityReferences
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