Asian Journal of Research in Chemistry

S. R. Bavaskar ¹, A. D. Agrawal ¹, Y. S. Agrawal ¹, A. N. Amrutkar ¹, Niraj L. Badhe ¹, P. S. Kawatikwar ¹

Affiliations
1 Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, Jamner, Jalgaon Dist, IN

Abstract

A simple, sensitive, accurate and precise UV Spectrophotometric method has been developed for quantitative determination of Tramadol Hydrochloride in bulk and tablet formulations. The UV-spectrum was scanned between 220 to 400 nm and 270.5 nm was selected as maximum wavelength for absorption. Tramadol shows molar absorptivity of 1.771×10⁴ l/mol/cm and Sandell’s sensitivity 0.16927 mcg/Sq.cm/0.001-absorbance units. Beer’s law was obeyed in the concentration range of 15-170 μg/ml. Results of analysis were validated statistically and by recovery studies.

Keywords

Tramadol Hydrochloride, Tablet, Ultraviolet Spectrophotometric Estimation.

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