Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Eco-friendly Synthesis of Novel Fluorine Containing 1,3,4-oxadiazoles as Antibacterial and Antifungal Agents


Affiliations
1 Department of Chemistry, Veer Narmad South Gujarat University, Surat -395 007
     

   Subscribe/Renew Journal


Title compounds of 1,3,4-oxadiazoles derivatives by the ring closure reaction of m-fluorobenzoic acid hydrazide with an aromatic acid and alumina in presence of POCl3 under microwave irradiation. All the newly synthesized compounds were screened for their antibacterial activity against Gram-positive bacteria namely staphylococcus aureus, Bacillus subtilis and Gram-negative bacteria namely, Escherichia coli and Pseudomonas aeruginosa. All the synthesized compounds were also tested for their antifungal activity against fungi namely, Candida albicans.

Keywords

2,5-disubstituted 1,3,4-oxadiazoles, Ring Closure Reaction, Antibacterial Activity, Antifungal Activity
Subscription Login to verify subscription
User
Notifications
Font Size


  • Pinaki Sen Gupta, Deepak Kumar Das, Veerendra C. Yeligar, K Muragesh, T. K. Maily. Evaluation of anticancer activity of some 1,3,4-oxadiazole derivatives. Ind. J. Chem.47(B);2008:460-462.
  • B. Jayashankar, K M. Lokanath Rai, N. Baskuran, H.S. Sathis. Synthesis and pharmacological evaluation of 1,3,4-oxadiazole bearing bis(heterocycle) derivatives as anti-inflammatory and analgesic agents. Eur. J. Med.Chem.44;2009:3898-3902.
  • Om Prakash, Manojkumar, Rajeshkumar, Chetan Sharmah, K. R. Aneja. Hypervalent iodine(III) mediated synthesis of novel unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles as antibacterial and antifungal agents. Eur. J. Med. Chem. 45;2010:4252-4257.
  • Sashikant R. Pattan, P. A. Rabara, Jayshree S. Pattan. Synthesis and evaluation of some novel substituted 1,3,4-oxadiazole and pyrazole derivatives for antitubercular activity. Ind. J. Chem. 48B; 2009:1453-1456.
  • K. M. Khan, Zia, Ullah, M. Rani, S. Perveen, S. M. Haider, N. L. Choudary, Atta-Ur Rehman, W. Voelter.Microwave-Assisted Synthesis of 2,5-Disubstituted-1,3,4-Oxadiazoles. Lett. Org. Chem. 1; 2004:50-52.
  • S. Liraz, M.P. Allen, B. E. Segelstein. A Mild Method for the Preparation of 1,3,4-Oxadiazoles: Triflic Anhydride Promoted Cyclization of Diacylhydrazines Synth. Commun.30;2000:437- 443.
  • E. Jedlovska, J. usko. A Simple One-Pot Procedure for the Synthesis of 1,3,4-Oxadiazoles. Synth. Commun. 24(13); 1994: 1879-1885.
  • M. Dabiri, P. Salehi, M. Baghbanzadeh, M. Bahramnejad. A facile procedure for the one-pot synthesis of unsymmetrical 2,5- disubstituted 1,3,4-oxadiazoles Tett. Lett. 47 (39); 2006: 6983- 6986.
  • R. Milcent, G. J. Barbier, Oxydation D'hydrazones par le bioxyde De Plomb: Nouvelles Synthèses d'oxadiazoles-1,3,4 et de dérivés de l'amino-4 triazol-1,2,4 one-5. J. of Heterocycle Chem. 1(20) ;1983:77-80.
  • H. Saikahi, N. Shimojo, Y. Uehara, Synthesis of Furan Derivatives. LIX. Synthesis of 5-Substituted-2-(2-furyl)-1,3,4- oxadiazoles from 1-Furoyl-2-arylidenehydrazine with Lead Tetraacetate Chem. Pharma Bull.20(12);1972:1663-1668.
  • S. Roslamizadeh, S.A. Ghasem, Housaini. Microwave assisted syntheses of 2,5-disubstituted 1,3,4-oxadiazolesTett. Lett. 45 (47); 2004: 8753-8756.

Abstract Views: 116

PDF Views: 0




  • Eco-friendly Synthesis of Novel Fluorine Containing 1,3,4-oxadiazoles as Antibacterial and Antifungal Agents

Abstract Views: 116  |  PDF Views: 0

Authors

Ajay N. Mehta
Department of Chemistry, Veer Narmad South Gujarat University, Surat -395 007
Jayraj Yadav
Department of Chemistry, Veer Narmad South Gujarat University, Surat -395 007
K.R. Desai
Department of Chemistry, Veer Narmad South Gujarat University, Surat -395 007

Abstract


Title compounds of 1,3,4-oxadiazoles derivatives by the ring closure reaction of m-fluorobenzoic acid hydrazide with an aromatic acid and alumina in presence of POCl3 under microwave irradiation. All the newly synthesized compounds were screened for their antibacterial activity against Gram-positive bacteria namely staphylococcus aureus, Bacillus subtilis and Gram-negative bacteria namely, Escherichia coli and Pseudomonas aeruginosa. All the synthesized compounds were also tested for their antifungal activity against fungi namely, Candida albicans.

Keywords


2,5-disubstituted 1,3,4-oxadiazoles, Ring Closure Reaction, Antibacterial Activity, Antifungal Activity

References