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Synthesis, Characterization, Equilibrium Studies and Antibacterial Studies of Co(II) Complex with Schiff Base Ligand Derived from Pyridoxal and 2,4-Dichlorobenzohydrazide


Affiliations
1 Department of Chemistry, Nizam College, OU, Basheerbagh, Hyderabad-500001, Telangana, India
2 Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad-500085, Telangana, India
     

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The Co(II) metal (M) complex of 2,4-dichloro-N-((3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl)methylene)benzohydrazide (L) was synthesized and characterized by elemental analysis, molar conductance, magnetic moment measurements, LC-MS, IR, TGA and UV spectral studies. Irving-Rossetti titration method was employed to determine the acid dissociation constant of ligand and the stability constant of Co(II) complex in 70% (v/v) DMF-water medium at 0.1 M KNO3 ionic strength and 303K temperature. The spectroanalytical data indicate the composition of the complexes to be 1:2 (ML2) with octahedral geometry. The ligand and the complex were screened for their antibacterial activity against Gram positive and Gram negative bacteria using agar well diffusion method.

Keywords

Pyridoxal, Schiff Base, Complex, Stability Constant, Antibacterial Activity.
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  • Synthesis, Characterization, Equilibrium Studies and Antibacterial Studies of Co(II) Complex with Schiff Base Ligand Derived from Pyridoxal and 2,4-Dichlorobenzohydrazide

Abstract Views: 81  |  PDF Views: 5

Authors

R. Kavitha
Department of Chemistry, Nizam College, OU, Basheerbagh, Hyderabad-500001, Telangana, India
Venkata Ramana Reddy
Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad-500085, Telangana, India
B. Sireesha
Department of Chemistry, Nizam College, OU, Basheerbagh, Hyderabad-500001, Telangana, India

Abstract


The Co(II) metal (M) complex of 2,4-dichloro-N-((3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl)methylene)benzohydrazide (L) was synthesized and characterized by elemental analysis, molar conductance, magnetic moment measurements, LC-MS, IR, TGA and UV spectral studies. Irving-Rossetti titration method was employed to determine the acid dissociation constant of ligand and the stability constant of Co(II) complex in 70% (v/v) DMF-water medium at 0.1 M KNO3 ionic strength and 303K temperature. The spectroanalytical data indicate the composition of the complexes to be 1:2 (ML2) with octahedral geometry. The ligand and the complex were screened for their antibacterial activity against Gram positive and Gram negative bacteria using agar well diffusion method.

Keywords


Pyridoxal, Schiff Base, Complex, Stability Constant, Antibacterial Activity.