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Synthesis and Biological Activities of Novel Thieno[3, 2-d] Pyrimidine Derivatives


Affiliations
1 SVR Engineering College, Jawaharlal Nehru Technological University-Ananthapuramu (Jntu-A), Nandyal, Kurnool (Dist), A.P., India
2 Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, (AP), India
3 PBR VITS, Jawaharlal Nehru Technological University (Jntu-A), Kavali, Nellore (Dist), (A.P.), India
     

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A series of novel 4-Substituted/Heterocyclic-N-(4-thiomorpholinothieno[3,2-d]pyrimidin-2-yl)benzamide (8a-j) derivatives were synthesized by a Five-step procedure that afforded advantages of mild reaction conditions, simple protocol and good yields. The structures of the final compounds were confirmed by IR, NMR, EI-MS. The final compounds were screened for their anti-bacterial activity against Staphylococcus aureus (S. aureus) and Bacillus subtilis (B. subtilis)from Gram positive group of bacteria and Pseudomonas aeruginosa (P. aeruginosa) and Escherichia coli (E. coli) from Gram negative group of bacteria and antifungal activity against Aspergillus niger (A. niger) and Candida albicans (C. albicans). Anti-bacterial and anti-fungal activities were Evaluated and compared with the standard drugsSuch asAmoxicillin &Flucanazole From anti-bacterial and antifungal activity screening results, it has been observed that compounds 8j, 8i, 8e and 8f possess good activity.

Keywords

Thieno [3, 2-d] Pyrimidine, 2-Chloro-4-Thio Morpholine Thieno[3, 2-d]Pyrimidine Synthesis, Anti-Bacterial, Anti-Fungal Activity, HATU.
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  • Synthesis and Biological Activities of Novel Thieno[3, 2-d] Pyrimidine Derivatives

Abstract Views: 66  |  PDF Views: 7

Authors

Virupakshi Prabhakar
SVR Engineering College, Jawaharlal Nehru Technological University-Ananthapuramu (Jntu-A), Nandyal, Kurnool (Dist), A.P., India
K. Sudhakar Babu
Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, (AP), India
L. K. Ravindranath
Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, (AP), India
B. Venkateswarlu
PBR VITS, Jawaharlal Nehru Technological University (Jntu-A), Kavali, Nellore (Dist), (A.P.), India

Abstract


A series of novel 4-Substituted/Heterocyclic-N-(4-thiomorpholinothieno[3,2-d]pyrimidin-2-yl)benzamide (8a-j) derivatives were synthesized by a Five-step procedure that afforded advantages of mild reaction conditions, simple protocol and good yields. The structures of the final compounds were confirmed by IR, NMR, EI-MS. The final compounds were screened for their anti-bacterial activity against Staphylococcus aureus (S. aureus) and Bacillus subtilis (B. subtilis)from Gram positive group of bacteria and Pseudomonas aeruginosa (P. aeruginosa) and Escherichia coli (E. coli) from Gram negative group of bacteria and antifungal activity against Aspergillus niger (A. niger) and Candida albicans (C. albicans). Anti-bacterial and anti-fungal activities were Evaluated and compared with the standard drugsSuch asAmoxicillin &Flucanazole From anti-bacterial and antifungal activity screening results, it has been observed that compounds 8j, 8i, 8e and 8f possess good activity.

Keywords


Thieno [3, 2-d] Pyrimidine, 2-Chloro-4-Thio Morpholine Thieno[3, 2-d]Pyrimidine Synthesis, Anti-Bacterial, Anti-Fungal Activity, HATU.