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Anti Obesity Activity of Rhynchosia beddomei by Using Progesteron Induced Obesity in Mice, and Mono Sodium Glutamate Induced Obesity in Rats


Affiliations
1 Department of Pharmacology, Azad College of Pharmacy, Moinabad-Chilkur Road, Hyderabad-500075, India
     

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Vendu chettu (Rhynchosia beddomei) Whole plant is ascribed with many therapeutic effects. The present study was undertaken to explore the anti-hyperlipidemic effect of four different extracts viz. Methanol, chloroform, alcoholic and aqueous extracts from Vendu chettu in Progesterone and Mono sodium gluconate induced hyperlipidemic rats and their hypolipidemic effects in normocholesteremic rats. The study is comprised preliminary phytochemical screening of the extracts. Oral administration of the extracts, at doses of 100, 200 and 400 mg/kg body weight in rats, dose-dependently inhibited the total cholesterol, triglycerides, low-density lipoproteins level, and significantly increased the high density lipoproteins level. Only methanolic extract exhibited more significant effects in lowering total cholesterol triglycerides and low density lipoproteins along with increase in HDL as compared to the others. Preliminary phytochemical screening revealed the presence of Alkaloids, Anthracene glycosides, Anthraquinones and Caratinoids, Coumarins, Flavonoids, Gallic tannins, Saponins Triterpenoids, Volatile oils are reported in the Leaf extract. The results obtained suggest marked antihyperlipidemic and hypolipidemic activity of the Whole plant extracts.

Keywords

Hypolipidemic, Rhynchosia beddomei, Progesterone, Sibutramine.
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  • Anti Obesity Activity of Rhynchosia beddomei by Using Progesteron Induced Obesity in Mice, and Mono Sodium Glutamate Induced Obesity in Rats

Abstract Views: 73  |  PDF Views: 6

Authors

Habeeba Sultana
Department of Pharmacology, Azad College of Pharmacy, Moinabad-Chilkur Road, Hyderabad-500075, India
Tahseen Sameena
Department of Pharmacology, Azad College of Pharmacy, Moinabad-Chilkur Road, Hyderabad-500075, India
Hafsa Siddiqua
Department of Pharmacology, Azad College of Pharmacy, Moinabad-Chilkur Road, Hyderabad-500075, India
Kouser Unnisa
Department of Pharmacology, Azad College of Pharmacy, Moinabad-Chilkur Road, Hyderabad-500075, India

Abstract


Vendu chettu (Rhynchosia beddomei) Whole plant is ascribed with many therapeutic effects. The present study was undertaken to explore the anti-hyperlipidemic effect of four different extracts viz. Methanol, chloroform, alcoholic and aqueous extracts from Vendu chettu in Progesterone and Mono sodium gluconate induced hyperlipidemic rats and their hypolipidemic effects in normocholesteremic rats. The study is comprised preliminary phytochemical screening of the extracts. Oral administration of the extracts, at doses of 100, 200 and 400 mg/kg body weight in rats, dose-dependently inhibited the total cholesterol, triglycerides, low-density lipoproteins level, and significantly increased the high density lipoproteins level. Only methanolic extract exhibited more significant effects in lowering total cholesterol triglycerides and low density lipoproteins along with increase in HDL as compared to the others. Preliminary phytochemical screening revealed the presence of Alkaloids, Anthracene glycosides, Anthraquinones and Caratinoids, Coumarins, Flavonoids, Gallic tannins, Saponins Triterpenoids, Volatile oils are reported in the Leaf extract. The results obtained suggest marked antihyperlipidemic and hypolipidemic activity of the Whole plant extracts.

Keywords


Hypolipidemic, Rhynchosia beddomei, Progesterone, Sibutramine.