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An Efficient Nickel Chloride Catalyzed Multi-Component Condensation of Indole with Carbonyl Compounds in PEG-400 as a Green Medium at Ambient Conditions


Affiliations
1 Post Graduate and Research Centre, Dr. Rafiq Zakaria Campus, Maulana Azad College, Rauza Baugh, Aurangabad, 431001, India
     

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Bis (indolyl) methane derivatives were efficiently synthesized by the condensation reaction of various aromatic aldehydes and indole in presence of nickel chloride as a Lewis acid catalyst in PEG-400 as a recyclable green solvent at room temperature. The use of PEG-400 and nickel chloride offers improvements for the synthesis of bis (indoyl) methanes with regard to the yield of products, short reaction times and green aspects utilizing recyclable and non volatile medium and avoiding any volatile and hazardous organic solvent.

Keywords

Bis (Indolyl) Methane, Nicke (II) Chloride, PEG-400.
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  • An Efficient Nickel Chloride Catalyzed Multi-Component Condensation of Indole with Carbonyl Compounds in PEG-400 as a Green Medium at Ambient Conditions

Abstract Views: 56  |  PDF Views: 6

Authors

Syed Nazimuddin
Post Graduate and Research Centre, Dr. Rafiq Zakaria Campus, Maulana Azad College, Rauza Baugh, Aurangabad, 431001, India
Maqdoom Farooqui
Post Graduate and Research Centre, Dr. Rafiq Zakaria Campus, Maulana Azad College, Rauza Baugh, Aurangabad, 431001, India

Abstract


Bis (indolyl) methane derivatives were efficiently synthesized by the condensation reaction of various aromatic aldehydes and indole in presence of nickel chloride as a Lewis acid catalyst in PEG-400 as a recyclable green solvent at room temperature. The use of PEG-400 and nickel chloride offers improvements for the synthesis of bis (indoyl) methanes with regard to the yield of products, short reaction times and green aspects utilizing recyclable and non volatile medium and avoiding any volatile and hazardous organic solvent.

Keywords


Bis (Indolyl) Methane, Nicke (II) Chloride, PEG-400.