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Pandit, Vinay
- Natural and Synthetic Polymers for Colon Targeted Drug Delivery
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Authors
Affiliations
1 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Kangra (H.P)-177101, IN
1 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Kangra (H.P)-177101, IN
Source
Asian Journal of Pharmacy and Technology, Vol 6, No 1 (2016), Pagination: 35-44Abstract
Colon targeted drug delivery system have recently gained importance in delivery of number of therapeutic agents for both local and systemic action. Colon targeted drug delivery system is useful for delivery of proteins and peptides, drugs undergoing degradation in stomach and small intestine. Targeting of drugs to colon is also favorable for the chronotherapy of diseases. To achieve successful, colonic delivery, a drug is needed to be protected from absorption in upper gastrointestinal tract (GIT). Out of the several approaches for colon targeting, coating the drug core with a polymer or polymer combinations is an important strategy. Coating of drug core with a pH dependent polymer or a polymer biodegraded in colon by colonic flora has been widely investigated approach for colonic delivery. Polysaccharides are important polymers from either natural or synthetic origin which have been exhaustively studied for successful colon targeting. This review describes some important natural and synthetic polysaccharides and polymers investigated for colonic drug delivery by coating the drug core.Keywords
Colon, Polymer, Coating, Biodegradation, Polysaccharide.
- Gold Nanoparticle-Small Drug Molecule Conjugates:Therapeutic Applications and Benefits as Compared to Free Drug
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Authors
Affiliations
1 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kangra, H. P., IN
1 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kangra, H. P., IN
Source
Asian Journal of Pharmacy and Technology, Vol 8, No 1 (2018), Pagination: 52-62Abstract
Gold nanoparticles (AuNPs) have been profoundly investigated for drug delivery applications. Various widely used small drugs molecules when conjugated either covalently or non-covalently with the AuNPs, showed improved therapeutic effect with reduced dose and adverse effects as compared to drug alone. This review focuses on therapeutic efficiency of AuNPs-small drug molecule conjugates as anti-cancer, anti-bacterial, antiretroviral and anti-arthritic agents. The basic approaches of conjugation, brief of procedure followed for activity determination and mechanism of action of conjugates have also been discussed.Keywords
Gold, Nanoparticles, Drug Conjugates, Anti-Cancer, Anti-Bacterial, Drug Delivery.References
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- Application of Nanocarrier in Drug development with special Emphasis on Liposomes: A Review
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Authors
Anshul Sharma
1,
Keshav Dhiman
1,
Anshul Sharma
1,
Kamya Goyal
2,
Vinay Pandit
1,
M. S. Ashawat
1,
Shammy Jindal
1
Affiliations
1 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog Jawalaji Dist - Kangra (H.P.), IN
2 Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog Jawalaji Dist - Kangra (H.P.), IN
1 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog Jawalaji Dist - Kangra (H.P.), IN
2 Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog Jawalaji Dist - Kangra (H.P.), IN
Source
Asian Journal of Pharmacy and Technology, Vol 12, No 4 (2022), Pagination: 320-328Abstract
Liposomes are the nano-scale bilayer structure of phospholipid used as a carrier for a Large Variety of drugs. Both lipophilic and hydrophilic drugs can encapsulate into the liposome and delivered to the body. The purpose behind the preparation of liposomes is to reduce the side effects associated with systemic delivery of drugs as well as it also helps in the protection of biodegradable drugs and molecules such as protein and peptides from body enzymes and fluids. Other than these advantages liposome also have high skin permeation due to structural similarities with the stratum corneum and therefore can be used for the topical delivery of drugs. The various types of liposomes and their application in their marketed products are discussed below in the article.Keywords
Liposome, Gene Therapy, Theranostic ApplicationsReferences
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