Asian Journal of Pharmacy and Technology

Chinmaya Keshari Sahoo ¹, K. Satyanarayana ², D. Venkata Ramana ³, Kanhu Charan Panda ⁴

Affiliations
1 Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Telangana-500014, IN
2 Department of Pharmacognosy, Princeton College of Pharmacy, Korremula, Ghatkesar, R. R. District, Telangana-500088, IN
3 Department of Pharmaceutical Technology, Netaji Institute of Pharmaceutical Sciences, Toopranpet, Yadadri Bhongir, Telangana-508252, IN
4 Department of Pharmaceutics, Anwarul Uloom College of Pharmacy, Newmallepally, Hyderabad, Telangana, IN

Abstract

The present work was aimed to develop controlled release tablets of aspirin. Direct compression technique was adopted for the preparation of all these formulations. The developed tablets were evaluated for pre compression parameters; post compression parameters, in vitro dissolution study. Among all the developed batches ASF3 showed highest drug release 96.14% at the end of 10 h. The optimized formulation was found to be stable up to 3 months when tested for stability study at 40±2ºC/ 75±5% RH.

Keywords

Aspirin, Direct Compression, in vitro Drug Release, Stability Study.

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Chinmaya Keshari Sahoo ¹, Surepalli Ram Mohan Rao ², Muvvala Sudhakar ³, D. Venkata Ramana ⁴, K. Satyanarayana ⁵

Affiliations
1 Department of Pharmaceutics, Faculty of Pharmacy, University College of Technology, Osmania University, Hyderabad, Telangana - 500007, IN
2 Mekelle Institute of Technology, Mekelle University, Mekelle, ET
3 Department of pharmaceutics, Malla Reddy College of Pharmacy (Affiliated to Osmania University), Maisammaguda, Secunderabad, Telangana - 500014, IN
4 Department of pharmaceutical Technology, Netaji Institute of Pharmaceutical Sciences, Toopranpet, Yadadri Bhongir, Telangana - 508252, IN
5 Department of Pharmacognosy, Princeton College of Pharmacy, Korremula, Ghatkesar, R.R. District, Telangana - 500088, IN

Abstract

The current research involves the development of controlled porosity osmotic pump (CPOP) tablets of ritonavir for the treatment of HIV infection. Core tablets were prepared by wet granulation method using hydroxyl propyl methyl cellulose (HPMCE5LV) polymer, mannitol as osmogen, MCC as diluents and other additives. The CPOP tablets were coated with cellulose acetate as wall forming material, poly ethylene glycol as flux regulating agent, and sorbitol acts as pore forming material in SPM. The prepared tablets were evaluated for FTIR, DSC, precompression parameters, post compression parameters, in vitro drug release study and scanning electron microscopy study. The optimized formulation RM5 showed 94.83% at the end of 14 hrs with zero order drug release. The difference factor (f1) and similarity factor (f2) for RM5 were observed 14.61 and 75.12 respectively. Optimized formulation did not show any significant change on the p^H and agitation intensity, but it depends on osmotic pressure of dissolution media indicated that mechanism of drug release was due to osmotic pressure. SEM micrographs confirmed that no pores were found before dissolution and after dissolution had shown the porous nature of the membrane. Short term stability study at 40 ± 2 °C/75 ± 5% RH for three months on the RM5 formulation indicated that there was no significant change weight variation, %friability, drug content and in vitro drug release.

Keywords

Ritonavir, Wet Granulation, CPOP, Difference Factor, In Vitro Drug Release, Stability Study.

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