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Ali, Javed
- Assessment of Phase Diagrams by Cut and Weigh Method: A Technical Note
Authors
1 Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi–110062, IN
2 Department of Pharmacognosy & Phytochemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi – 110062, IN
Source
Asian Journal of Pharmacy and Technology, Vol 3, No 3 (2013), Pagination: 102-104Abstract
A good number of manuscripts are being published where the authors carry out qualitative assessment of the region of interest in the phase diagrams. These qualitative assessments can be sensed as a lack of sound technique for quantitative assessment. In the present technical note we have developed a simple cut and weigh method to offer a quantitative method for assessing phase diagrams. The method was validated and explained using sample analysis. The method was found to be robust, quantitative and enabled statistical comparison of the results. The method was found to be excellent even when applied for samples below a weight of 10 mg and that too on different paper sheets. The suggested technique of expressing the result as a percentage of the total area could offer a universal applicability of the method for assessment of phase diagrams. The developed and validated method would be a great tool for the researchers requiring quantitative assessment of phase diagrams.Keywords
Nanoemulsion, Microemulsion, Validation, p valueReferences
- Bali V, Ali M, Ali J: Nanocarrier for the enhanced bioavailability of a cardiovascular agent: in vitro, pharmacodynamic, pharmacokinetic and stability assessment. Int J Pharm. 403; 2011:46-56. /2. Parveen R, Baboota S, Ali J, Ahuja A, Vasudev SS, Ahmad S: Oil based nanocarrier for improved oral delivery of silymarin: In vitro and in vivo studies. Int J Pharm. 413; 2011: 245-53.
- Bali V, Ali M, Ali J: Novel nanoemulsion for minimizing variations in bioavailability of ezetimibe. J Drug Target. 18; 2010: 506-519.
- Bali V, Ali M, Ali J: Study of surfactant combinations and development of a novel nanoemulsion for minimising variations in bioavailability of ezetimibe. Colloids Surf B Biointerfaces. 76; 2010: 410-420.
- Kawtikwar PS, Kulkarni NP, Yadav S, Sakarkar DM: Formulation and evaluation of an anti-epileptic drug-loaded microemulsion for nose to brain delivery. Asian J Pharm. 3; 2009:143-147.
- Zhu W, Guo C, Yu A, Gao Y, Cao F, Zhai G: Microemulsionbased hydrogel formulation of penciclovir for topical delivery. Int J Pharm. 378; 2009:152-158.
- Shakeel F, Baboota S, Ahuja A, Ali J, Aqil M, Shafiq S: Nanoemulsions as Vehicles for Transdermal Delivery of Aceclofenac. AAPS PharmSciTech. 8; 2007: E1-E9.
- Shafiq S, Shakeel F, Talegaonkar S, Ahmad FJ, Khar RK, Ali M: Development and bioavailability assessment of ramipril nanoemulsion formulation. Eur J Pharm Biopharm. 66; 2007: 227-243.
- Shafiq-un-Nabi S, Shakeel F, Talegaonkar S, Ali J, Baboota S, Ahuja A, Khar RK, Ali M: Formulation Development and Optimization Using Nanoemulsion Technique: A Technical Note. AAPS PharmSciTech. 8(2); 2007: E1-E6.
- Validated UPLC/Q-TOF-MS Method for Simultaneous Determination of Metformin, Glimepiride and Pioglitazone in Human Plasma and its Application to Pharmacokinetic Study
Authors
1 JK College of Pharmacy, Bilaspur, CG, 495001, IN
2 Department of Pharmaceutics, Hamdard University, New Delhi, 110062, IN
Source
Asian Journal of Pharmacy and Technology, Vol 7, No 1 (2017), Pagination: 27-32Abstract
In the presented work the ultra-performance liquid chromatographic/quadrupole time-of-flight mass spectrometric (UPLC/Q-TOF-MS) method has been developed for simultaneous determination of metformin, glimepiride and pioglitazone in human plasma. For identification of drugs, the Q-TOF mass spectrometer was operated in positive ionization mode and quantification was done using the MS/MS transitions at m/z 130.0 to 71.0 for metformin, 491.00 to 352.00 for glimepiride and 357.00 to 134.00 for pioglitazone. The chromatographic separation was achieved on Acquity UPLCTM BEH C18 (100.0 × 2.1 mm, 1.7μm) column using isocratic mobile phase consisting of acetonitrile-2mM ammonium acetate (50:50, v/v) at a flow rate of 0.20 mL/min. The elution of metformin, glimepiride and pioglitazone was occurred at 0.50, 1.40 and 1.22 min, respectively. The calibration curves were linear over the concentration range of 1-1000 ng/mL for all the drugs. The developed method was validated according to ICH guidelines. The method was applied for pharmacokinetic study of drugs in FDC tablets in human plasma.