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Formulation and Evaluation of Mouth Dissolving Tablets of Zolmitriptan


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1 Department of Pharmaceutics, S.G.S.S's Loknete Dr. J. D. Pawar College of Pharmacy, Manur, Kalwan, India
     

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The objective of present study was to formulate mouth dissolving tablets of Zolmitriptan. Zolmitriptan is a 5-HT receptor agonist. It is used in the treatment of migraine. Six different formulations of Zolmitriptan mouth dissolving tablets were prepared by using direct compression technique by using different concentrations of AC-Di-Sol, Avicel pH 101 and strlac. Tablets were evaluated for different precompression and post compression parameters of tablets were carried out and the results satisfies according to the pharmacopoeia specifications. Other parameters such as drug-excipients compatibility were also evaluated through IR and DSC study.IR and DSC studies revelled that there is no interaction between drug and different excipients used in formulation. Formulation F6 was selected as optimised formulation showing better dissolution results at 35 minutes.

Keywords

Zolmitriptan, Mouth Dissolving Tablets, Ac-Di-Sol, Antimigraine.
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  • Formulation and Evaluation of Mouth Dissolving Tablets of Zolmitriptan

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Authors

Vaishali B. Morade
Department of Pharmaceutics, S.G.S.S's Loknete Dr. J. D. Pawar College of Pharmacy, Manur, Kalwan, India
Vandana R. Daga
Department of Pharmaceutics, S.G.S.S's Loknete Dr. J. D. Pawar College of Pharmacy, Manur, Kalwan, India
Prashant R. Malpure
Department of Pharmaceutics, S.G.S.S's Loknete Dr. J. D. Pawar College of Pharmacy, Manur, Kalwan, India

Abstract


The objective of present study was to formulate mouth dissolving tablets of Zolmitriptan. Zolmitriptan is a 5-HT receptor agonist. It is used in the treatment of migraine. Six different formulations of Zolmitriptan mouth dissolving tablets were prepared by using direct compression technique by using different concentrations of AC-Di-Sol, Avicel pH 101 and strlac. Tablets were evaluated for different precompression and post compression parameters of tablets were carried out and the results satisfies according to the pharmacopoeia specifications. Other parameters such as drug-excipients compatibility were also evaluated through IR and DSC study.IR and DSC studies revelled that there is no interaction between drug and different excipients used in formulation. Formulation F6 was selected as optimised formulation showing better dissolution results at 35 minutes.

Keywords


Zolmitriptan, Mouth Dissolving Tablets, Ac-Di-Sol, Antimigraine.

References