Asian Journal of Pharmacy and Technology

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Formulation and Evaluation of Oro Dispersible Tablets of Atenolol by Sublimation Method


Affiliations
1 Department of Pharmaceutics, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana – 502312, India
2 Department of Pharmaceutics, Talla Padmavathi College of Pharmacy, karreeemabad Bodrai (V), Warangal (D), Telangana – 506012, India
3 Department of Pharmaceutical Chemistry, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana – 502312, India
4 Department of Pharmacology, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana – 502312, India
     

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The present study aims to formulate and evaluate oro dispersible tablets of Atenolol, a drug that is used for the treatment of chest pain (angina) was prepared by using sublimation method and also optimize the best formulation. The study involved different excipients which were tested for their compatibility with Atenolol by the FT-IR studies. Based on the results of FT-IR studies, majority of the excipients were found to be compatible with Atenolol which were used for the preparation of Atenolol oral disintegrating tablets. Oral disintegrating tablets of Atenolol were prepared by direct compression method by the addition of subliming agents. Twelve batches (H1-H12) of oral disintegrating tablets of Atenolol were prepared by using Subliming agents like Ammonium Carbonate, Camphor, Thymol and Menthol in variable concentrations along with other excipients for the development of optimized formulation. All the formulations were subjected to evaluation studies of weight variation, hardness, friability, drug content, Wetting time, in-vitro disintegration, in vitro-dissolution studies and are found to be within the limits.

Keywords

Oro Dispersible Tablet (ODT), Atenolol, Direct Compression, Sublimation Method, Anti Angina Activity.
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  • Formulation and Evaluation of Oro Dispersible Tablets of Atenolol by Sublimation Method

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Authors

Nirmala Rangu
Department of Pharmaceutics, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana – 502312, India
B. Chaitanya Kumari
Department of Pharmaceutics, Talla Padmavathi College of Pharmacy, karreeemabad Bodrai (V), Warangal (D), Telangana – 506012, India
Ganesh Akula
Department of Pharmaceutical Chemistry, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana – 502312, India
A. Jaswanth
Department of Pharmacology, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana – 502312, India

Abstract


The present study aims to formulate and evaluate oro dispersible tablets of Atenolol, a drug that is used for the treatment of chest pain (angina) was prepared by using sublimation method and also optimize the best formulation. The study involved different excipients which were tested for their compatibility with Atenolol by the FT-IR studies. Based on the results of FT-IR studies, majority of the excipients were found to be compatible with Atenolol which were used for the preparation of Atenolol oral disintegrating tablets. Oral disintegrating tablets of Atenolol were prepared by direct compression method by the addition of subliming agents. Twelve batches (H1-H12) of oral disintegrating tablets of Atenolol were prepared by using Subliming agents like Ammonium Carbonate, Camphor, Thymol and Menthol in variable concentrations along with other excipients for the development of optimized formulation. All the formulations were subjected to evaluation studies of weight variation, hardness, friability, drug content, Wetting time, in-vitro disintegration, in vitro-dissolution studies and are found to be within the limits.

Keywords


Oro Dispersible Tablet (ODT), Atenolol, Direct Compression, Sublimation Method, Anti Angina Activity.

References