Asian Journal of Pharmacy and Technology

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Antihyperlipidemic Effect of Stevia rebaudiana on Alloxan Induced Diabetic Rats


Affiliations
1 Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur, Kancheepuram Dist, Tamilnadu, India
2 Department of Pharmaceutics, Adhiparasakthi College of Pharmacy, Melmaruvathur, Kancheepuram Dist, Tamilnadu, India
3 Department of Pharmaceutical Chemistry, Adhiparasakthi College of Pharmacy, Melmaruvathur, Kancheepuram Dist, Tamilnadu, India
     

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Stevia rebaudiana is one of the main constituent of various herbal formulations available for diabetes. The present study was aimed at assessing the antihyperlipidemic (Total cholesterol and triglycerides) effect of the aqueous extract of Stevia rebaudiana in alloxan induced diabetic rats. The powdered leaf was successfully extracted with water using maceration process. The wistar strains of male albino rats were used for the present study. The aqueous extract of Stevia Rebaudiana was administered intraperitoneally injection as a dose of 60mg/kg body weight to alloxan induced diabetic rats and it was found to reduce blood lipid level significantly (p<0.05). The plant extraction also exhibit correction of altered biochemical parameters like SGOT and SGPT levels in diabetic rats. The study concluded that Stevia Rebaudiana possess hypolipidemic effect in experimental diabetic rats.

Keywords

Stevia rebaudiana, Triglycerides, Total Cholesterol, Serum Glutamic Oxaloacetic Transaminase (SGPT), Serum Glutamic Pyruvic Transaminase (SGPT).
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  • Antihyperlipidemic Effect of Stevia rebaudiana on Alloxan Induced Diabetic Rats

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Authors

T. Sudha
Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur, Kancheepuram Dist, Tamilnadu, India
D. Akila Devi
Department of Pharmaceutics, Adhiparasakthi College of Pharmacy, Melmaruvathur, Kancheepuram Dist, Tamilnadu, India
L. Kaviarasan
Department of Pharmaceutical Chemistry, Adhiparasakthi College of Pharmacy, Melmaruvathur, Kancheepuram Dist, Tamilnadu, India

Abstract


Stevia rebaudiana is one of the main constituent of various herbal formulations available for diabetes. The present study was aimed at assessing the antihyperlipidemic (Total cholesterol and triglycerides) effect of the aqueous extract of Stevia rebaudiana in alloxan induced diabetic rats. The powdered leaf was successfully extracted with water using maceration process. The wistar strains of male albino rats were used for the present study. The aqueous extract of Stevia Rebaudiana was administered intraperitoneally injection as a dose of 60mg/kg body weight to alloxan induced diabetic rats and it was found to reduce blood lipid level significantly (p<0.05). The plant extraction also exhibit correction of altered biochemical parameters like SGOT and SGPT levels in diabetic rats. The study concluded that Stevia Rebaudiana possess hypolipidemic effect in experimental diabetic rats.

Keywords


Stevia rebaudiana, Triglycerides, Total Cholesterol, Serum Glutamic Oxaloacetic Transaminase (SGPT), Serum Glutamic Pyruvic Transaminase (SGPT).

References