Asian Journal of Pharmacy and Technology

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Formulation Development of Propranolol Hydrochloride Sustained Release Prunus amygdalus Gum Based Mucoadhesive Buccal Matrices


Affiliations
1 Department of Pharmaceutics, Government College of Pharmacy, Kathora Naka, Amravati. 444604, India
     

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Sustaining the release of drug from dosage form is useful especially for achieving controlled plasma level of the drug as well as improving bioavailability. The objective of the present work was to develop sustained release propranolol hydrochloride mucoadhesive buccal matrix tablets using natural and synthetic polymers. Matrix tablets were prepared by direct compression method using backing layer on three sides of matrices and evaluated for various physical parameters. Quality control parameters followed by optimization was employed to get final optimized formulation. Among all the formulations, F8 shows 72.85% better sustained release at the end of 4.5 hrs. The release co-efficient values ‘n’ (>0.5) indicated that the drug release followed non-fickian anomalous mechanism based on formulation factors. The stability studies were carried out according to ICH guideline which indicates that the selected formulation was stable. Propranolol HCl matrices could be developed mucoadhesive nature with desirable release modulation for buccal administration.

Keywords

Propranolol HCl (PPPNL HCl), Prunus amygdalus Gum, Carbopol, Matrices.
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  • Boyapally H, Nukala RK, Bhujbal P and Douroumis D. Controlled release from directly compressible theophylline buccal tablets. Colloids and Surfaces B: Biointerfaces. 2010; 77(2):227-233.

  • Ikinci G et al. Development of a buccal bioadhesive nicotine tablet formulation for smoking cessation. International journal of pharmaceutics. 2004; 277(1): 173-178.

  • Shojaei AH. Buccal mucosa as a route for systemic drug delivery: a review. J Pharm Sci. 1998; 1(1):15-30.

  • Srikrishna T et al. Design, Development and Evaluation of Buccal Tablets of Pregabalin. Research J. Pharm. and Tech. 2017; 10(2):579-588.

  • Srikanth MV et al. Statistical design and evaluation of a propranolol HCl gastric floating tablet. Acta Pharmaceutica Sinica B. 2012; 2(1):60-69.

  • Meka VS, Nali SR, Songa AS and Kolapalli VR. Characterization and in vitro drug release studies of a natural polysaccharide Terminalia catappa gum (Badam gum). AAPS Pharm Sci Tech. 2012; 13(4): 1451-1464.

  • Prasanth BA et al. Effect of moringa gum in enhancing buccal drug delivery of propranolol hydrochloride. International journal of research in pharmacy and chemistr. 2011; 1(2):111-116.

  • Derle D et al. Formulation and evaluation of buccoadhesive bi-layer tablet of propranolol hydrochloride. International journal of pharmacy and Pharmaceutical Sciences. 2009; 1(1):206-212.

  • Harikrishnan V, Madhusudhan S and Santhiagu A. Evaluation of a Novel, Natural Badam Gum as a Sustained Release and Mucoadhesive Component of Tizanidine HCl Buccal Tablets. Asian J. Pharm. Tech. 2015; 5(2):71-78.

  • Shende MA and Marathe RP. Development and Optimization of Oral Gastroadhesive Matrices for Diltiazem Hydrochloride Using Some Natural Materials. Research J. Pharm. and Tech. 2016; 9(7):831-834.

  • Kumar P and Kulkarni GT. Characterization of mucilage from artocarpus heterophyllus as pharmaceutical excipient. Journal of Chronotherapy and Drug Delivery. 2013; 4(1):31-43.

  • Coates J. Interpretation of Infrared Spectra, a Practical Approach. John Wiley and Sons Ltd, Chichester, Meyers RA, editors. Encyclopedia of Analytical Chemistry. 2000; pp. 10815–10837.

  • Wadageri GV, Raju SA, Shirsand SB and Reddy VP. Buccal Drug Delivery System of Atenolol. Research J. Pharm. and Tech. 2012; 5(7): 894-900.

  • Nikam AP and Ratnaparkhi MP. Formulation and Evaluation of Losartan Potassium Sustained Release tablets. Research J. Pharm. and Tech. 2014; 7(11):1219-1225.

  • Lachman L, Lieberman HA, Kanig JL. The theory and practice of industrial pharmacy. Philadelphia: Lea and Febiger; Varghese Publishing House. 1990; 3rd Ed: pp. 199,329-335.

  • Deshmukh VN and Sakarkar DM. Development and Evaluation of Controlled Release Mucoadhesive Tablet. Research J. Pharm. and Tech. 2011; 4(4):578-581.

  • Patel VM, Prajapati BG and Patel MM. Formulation, evaluation, and comparison of bilayered and multilayered mucoadhesive buccal devices of propranolol hydrochloride. Aaps Pharmscitech. 2007; 8(1):E147-E154.

  • Bhanja S et al. Formulation and in-vitro evaluation of mucoadhesive buccal tablets of Timolol maleate. Int J Pharm Biomed Res. 2010; 1(4):129-134.

  • Kotadiya R, Patel V and Patel H. Hydrophilic Matrices Geometry, Swelling and Erosion Investigations to Clarify the Release Mechanism. Research J. Pharma. Dosage Forms and Tech. 2009; 1(3):191-195.

  • Nakamura F et al. In vitro and in vivo nasal mucoadhesion of some water-soluble polymers. International journal of pharmaceutics. 1996; 134(1-2):173-181.

  • Sirisha Y and Venkateswara Rao T. Formulation and Evaluation of Bilayered Buccal Adhesive Tablets of Carvedilol. Research J. Science and Tech. 2011; 3(6): 335-339.

  • Ravi Kumar V et al. Improvement of dissolution characteristics and bioavailability of tadalafil by solid dispersion technique using water soluble polymer. International Journal of Advanced Pharmaceuti. 2012; 2(2):56-63.

  • Patial JS. A Review on Stability and Instability in Fluids and Solids. Research J. Engineering and Tech.2012; 3(2): 171-175.


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  • Formulation Development of Propranolol Hydrochloride Sustained Release Prunus amygdalus Gum Based Mucoadhesive Buccal Matrices

Abstract Views: 243  |  PDF Views: 1

Authors

M. A. Shende
Department of Pharmaceutics, Government College of Pharmacy, Kathora Naka, Amravati. 444604, India
P. K. Gupta
Department of Pharmaceutics, Government College of Pharmacy, Kathora Naka, Amravati. 444604, India

Abstract


Sustaining the release of drug from dosage form is useful especially for achieving controlled plasma level of the drug as well as improving bioavailability. The objective of the present work was to develop sustained release propranolol hydrochloride mucoadhesive buccal matrix tablets using natural and synthetic polymers. Matrix tablets were prepared by direct compression method using backing layer on three sides of matrices and evaluated for various physical parameters. Quality control parameters followed by optimization was employed to get final optimized formulation. Among all the formulations, F8 shows 72.85% better sustained release at the end of 4.5 hrs. The release co-efficient values ‘n’ (>0.5) indicated that the drug release followed non-fickian anomalous mechanism based on formulation factors. The stability studies were carried out according to ICH guideline which indicates that the selected formulation was stable. Propranolol HCl matrices could be developed mucoadhesive nature with desirable release modulation for buccal administration.

Keywords


Propranolol HCl (PPPNL HCl), Prunus amygdalus Gum, Carbopol, Matrices.

References