Asian Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

A Review:Proniosomes as a Novel Drug Delivery System


Affiliations
1 Department of Quality Assurance Technique, MET’s BKC Institute of Pharmacy, Adgoan, Nashik-422101, India
     

   Subscribe/Renew Journal


Novel drug delivery system is a novel approach to drug delivery that addresses the limitations of traditional drug delivery systems and are able to deliver drug at the site of action and at predetermined rate which increases therapeutic efficacy, minimize adverse or side effects and increases bioavailability of the drug. Drug delivery system using colloidal particulate carriers such as liposomes and niosomes have distinct advantages over conventional dosage forms. However, remain significant problems like instability in general application of liposomes and niosomes for drug delivery. In recent time, proniosomal and niosomal system have been received a great attention in drug delivery applications as well as in pharmaceutical research. In order to minimize the problems associated with niosome physical stability such as aggregation, fusion and leaking and to provide additional convenience in transportation, distribution, storage and dosing etc, a dry product can be prepared, which is called proniosome. Proniosomes are dry formulation using suitable carrier coated with nonionic surfactants and can be converted into niosomes immediately before use by hydration. These proniosome-derived niosomes are as good as or even better than conventional niosomes. The current review deals with the trends, different aspects and the future perspective in the development of proniosomal drug delivery systems. (1, 2)

Keywords

Niosomes, Pronisomes, Surfactant, Stability, Bioavailability.
Subscription Login to verify subscription
User
Notifications
Font Size


  • D. Nagasamy Venkatesh, V. Swetha Priyanka, K. Tulasi, K. Kalyani, Sheik Abid Ali (2014), Harikrishna Jilakara Proniosomes: A Superior Drug Delivery System, International Journal of Pharmaceutical Sciences and Drug Research; 6(3): 178-182.

  • Mehta A.K., Dubal A.P., Mane P.D., Deshmukh HA (2013), recent trends in niosomes as nanocarriers, UJPB 2013 (02): Page 12-17.

  • Indira U and Uma Shankar M.S (2012), proniosomes as a drug carrier: a review, IJPSR, Vol. 3(12): 4617-4625.

  • Nadeem Farooqui, Vikas Jaiswal and Mousumi Kar (2013), A Review on Proniosomal Gel: Potential Carrier System in Transdermal Delivery for Non- Steroidal Anti-inflammatory Drugs (NSAID), 5(10):3939-3947.

  • Gyati Shilakari, Davinder Singh, Abhay Asthana1 (2013), Novel vesicular carriers for topical drug delivery and their application’s, Int. J. Pharm. Sci. Rev. Res., 21(1), no. 14, 77-86.

  • Trupti Anil Udasi, Vikrant P Wankhade, Latika, M. Ingle, Sandeep Atram , Kiran K. Tapar , proniosome: a novel approach to vesicular drug delivery system, International Journal of Pharmacy and Pharmaceutical Science Research

  • B. Agaiah Goudb, J.Rajub, D. Rambhaua (2012), improved oral absorption of carbamazepine from sorbitan monolaurate based proniosome systems containing charged surface ligands, B.

  • Agaiah Goud. et al. / International Journal of Biological and Pharmaceutical Research. 3(1): 37-42.

  • Shrishti Namdev, PreetiJamkar, SatishMandlik, Kishore Gujar (2014), recent trends in novel drug delivery for treatment of type i and ii diabetes mellitus, Asian Journal of Pharmaceutical Research and Development Vol. 2 (3) 54-69.

  • Walve J.R., Rane B.R., Gujrathi N.A., Bakaliwal S.R (2011), Proniosomes: Surrogated carrier for improved transdermal drug delivery system, Walve J.R. et al / IJRAP 2(3) 743-750/

  • Anchal Sankhyan and Pravin Pawar (2012), Recent Trends in Niosome as Vesicular Drug Delivery System, Journal of Applied Pharmaceutical Science 02 (06); 20-32.

  • Ajay Solanki, Jolly Parikh, Rasjesh Parikh (2008), Preparation, Characterization, Optimization, and Stability Studies of Aceclofenac Proniosomes, Article in Iranian journal of pharmaceutical research (IJPR).

  • Sahil Khindri, Geeta Aggarwal, SL Hari Kumar (2015), Role of niosomes and proniosomes for enhancing bioavailability of drugs, Khindri et al Journal of Drug Delivery and Therapeutics. 5(1):28-33.

  • Ankur Gupta, Sunil Kumar Prajapati, M Balamurugan, Mamta Singh, Daksh Bhatia (2007), Design and Development of a Proniosomal Transdermal Drug Delivery System for Captopril, Tropical Journal of Pharmaceutical Research, 6 (2): 687-693.

  • Didem Ag Seleci, Muharrem Seleci, Johanna-GabrielaWalter, Frank Stahl, and Thomas Scheper, Niosomes as Nanoparticular Drug Carriers: Fundamentals and Recent Applications, Hindawi Publishing Corporation Journal of Nanomaterials Volume 2016, Article ID 7372306, 13 pages.

  • Jadupati Malakar1, Prabir Kumar Datta1, Sanjay Dey1, Amites Gangopadhyay1 and Amit Kumar Nayak (2011), Proniosomes: a preferable carrier for drug delivery system, Jadupati Malakar et al./ Elixir Pharmacy 40 5120-5124.

  • Sharma BS, Bhogale V, Adepu AR, Patil ST, Sangha SK, Proniosomes : A Novel Provesicular Drug Delivery System, IJPRS/V4/I2/00062.

  • Mohamed Nasr (2010), In Vitro and In Vivo Evaluation of Proniosomes Containing Celecoxib for Oral Administration, AAPS Pharm Sci Tech. 11(1): 85–89.

  • Deepak Kumbhar, Preeti Wavikar, and Pradeep Vavia (2014), Niosomal Gel of Lornoxicam for Topical Delivery: In vitro Assessment and Pharmacodynamic Activity, AAPS PharmSciTech. 14(3): 1072–1082.

  • Mayur Gandhi1, Sanket Paralkar1, Mahendra Sonule1, Dhiraj Dabhade and Sagar Pagar (2014), Niosomes: Novel Drug Delivery System, Int. J. Pure App. Biosci. 2 (2): 267-274.

  • Aakash Parikh*, Siddharth Agarwal, Kirtesh Rau, (2014), a review on applications of maltodextrin in pharmaceutical INDUSTRY, IJPBS Volume4

  • Yasam Venkata Ramesh, N. Jawahar, Satya Lavanya Jakki (2013), Proniosomes: A Novel Nano Vesicular Transdermal Drug Delivery, J. Pharm. Sci. and Res. Vol.5(8), 153 – 158.

  • Samita Singla, S. L. HariKumar and Geeta Aggarwal (2012) “Proniosomes for Penetration Enhancement in Transdermal System”, Int. J. Drug Dev. and Res., 4(2):1-13doi:doinumber

  • Sudhamani.T*, Priyadarisini. N, Radhakrishnan. M, Proniosomes – A Promising Drug Carriers, International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN: 0974-4304 Vol.2, No.2, pp 1446-1454, April-June 2010.

  • Gamal M. El Maghraby, Amal A. Ahmed, and Mohamed A. Osman (2014), Penetration enhancers in proniosomes as a new strategy for enhanced transdermal drug delivery, Saudi Pharm J; 23(1): 67–74.doi: 10.1016/j.jsps.2014.05.001 PMCID: PMC4310994


Abstract Views: 265

PDF Views: 0




  • A Review:Proniosomes as a Novel Drug Delivery System

Abstract Views: 265  |  PDF Views: 0

Authors

R. Jangam Payal
Department of Quality Assurance Technique, MET’s BKC Institute of Pharmacy, Adgoan, Nashik-422101, India
A. Thombre Nilima
Department of Quality Assurance Technique, MET’s BKC Institute of Pharmacy, Adgoan, Nashik-422101, India
N. Gaikwad Pallavi
Department of Quality Assurance Technique, MET’s BKC Institute of Pharmacy, Adgoan, Nashik-422101, India

Abstract


Novel drug delivery system is a novel approach to drug delivery that addresses the limitations of traditional drug delivery systems and are able to deliver drug at the site of action and at predetermined rate which increases therapeutic efficacy, minimize adverse or side effects and increases bioavailability of the drug. Drug delivery system using colloidal particulate carriers such as liposomes and niosomes have distinct advantages over conventional dosage forms. However, remain significant problems like instability in general application of liposomes and niosomes for drug delivery. In recent time, proniosomal and niosomal system have been received a great attention in drug delivery applications as well as in pharmaceutical research. In order to minimize the problems associated with niosome physical stability such as aggregation, fusion and leaking and to provide additional convenience in transportation, distribution, storage and dosing etc, a dry product can be prepared, which is called proniosome. Proniosomes are dry formulation using suitable carrier coated with nonionic surfactants and can be converted into niosomes immediately before use by hydration. These proniosome-derived niosomes are as good as or even better than conventional niosomes. The current review deals with the trends, different aspects and the future perspective in the development of proniosomal drug delivery systems. (1, 2)

Keywords


Niosomes, Pronisomes, Surfactant, Stability, Bioavailability.

References