Asian Journal of Pharmaceutical Research

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Synthesis and Evaluation of Antidiabetic Activity of Few 5-(4-(5-Substitutedphenyl)-1,3,4-Oxadiazlole-2-Yl) Methoxy)Benzylidene) Thiazolidine 2,4-Dione Derivatives


Affiliations
1 MET’S Institute of Pharmacy, Bhujbal Knowledge City, Adgaon, Nashik-422003, Savitribai Phule Pune University, India
     

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The aim of study was to synthesize a new series of Thiazolidinedione. Thiazolidinedione or glitziness forms a significant class of drug which exhibit biological activities ranging from antidiabetic, antiinflamatory, antibacterial, antifungal, antiviral, and anti-cancer. In the present study reported a systematic synthesis of thiazolidinedione. A new series of 2,4-thiazolidinedione based derivative have been synthesize by condensation of. The structure of these compounds were establish by IR and 1H NMR. These new compound (C1-C4) were evaluated for their antidiabetic activity on albino rat. Most of compound shows significant antidiabetic activity when compare with standard drug metformin.

Keywords

Diabetic Mellitus, Thiazolidinedione, Antidiabetic Activity.
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  • Mohd Imran, deepanjali, suroor ahamd khan. Recent thiazolidinedione antidiabetic. Journal of scientific and industrial research vol 1 66 2007 February pp 99- 109.

  • Prashant B Mane, Rishikesh V Antre and Rajesh J Oswal. Antidiabetic Drugs: An Overview. INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND CHEMICAL SCIENCES.

  • Swapana D, Shivagami B, Manasa K. Synthesis ans evaluation of novel thiazolidinedione derivative of antidiabetic activity. International Research Journal of Pharmacy.

  • Rekha. S, Shantaram. U. SYNTHESIS AND EVALUATION OF NOVEL THIAZOLIDINEDIONES FOR ANTI DIABETIC ACTIVITY. International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491 Vol 3, Suppl 5, 2011

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  • Daniel J. Toft a, Miles Fuller a, Matthew Schipma b, Feng Chena, Vincent L. Cryns c αB-crystallin and HspB2 deficiency is protective from diet-induced glucose intolerance: www.elsevier.com

  • Donald McClain, Animal Models of Diabetic Complications Consortium Intraperitoneal Glucose Tolerance Testing (IPGTT) Version: 1.0

  • Amy R. Blair, Nadia Deluca, Barbara C. Fam, and Joseph Proietto Am. Evaluating the glucose tolerance test in mice Sofianos And rikopoulos. J Physiol Endocrinol Metab 295: E1323–E1332, 2008


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  • Synthesis and Evaluation of Antidiabetic Activity of Few 5-(4-(5-Substitutedphenyl)-1,3,4-Oxadiazlole-2-Yl) Methoxy)Benzylidene) Thiazolidine 2,4-Dione Derivatives

Abstract Views: 458  |  PDF Views: 0

Authors

Roshani Bhalerao
MET’S Institute of Pharmacy, Bhujbal Knowledge City, Adgaon, Nashik-422003, Savitribai Phule Pune University, India
Dinesh Rishipathak
MET’S Institute of Pharmacy, Bhujbal Knowledge City, Adgaon, Nashik-422003, Savitribai Phule Pune University, India
Pavan Udavant
MET’S Institute of Pharmacy, Bhujbal Knowledge City, Adgaon, Nashik-422003, Savitribai Phule Pune University, India
Sanjay Kshirsagar
MET’S Institute of Pharmacy, Bhujbal Knowledge City, Adgaon, Nashik-422003, Savitribai Phule Pune University, India

Abstract


The aim of study was to synthesize a new series of Thiazolidinedione. Thiazolidinedione or glitziness forms a significant class of drug which exhibit biological activities ranging from antidiabetic, antiinflamatory, antibacterial, antifungal, antiviral, and anti-cancer. In the present study reported a systematic synthesis of thiazolidinedione. A new series of 2,4-thiazolidinedione based derivative have been synthesize by condensation of. The structure of these compounds were establish by IR and 1H NMR. These new compound (C1-C4) were evaluated for their antidiabetic activity on albino rat. Most of compound shows significant antidiabetic activity when compare with standard drug metformin.

Keywords


Diabetic Mellitus, Thiazolidinedione, Antidiabetic Activity.

References