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Sharma, Sandeep
- Detection of Polymorphism of ATM Gene in Leukemia
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Authors
Affiliations
1 Department of Molecular and Cellular Engineering, Sam Higginbottom Institute of Agriculture, Technology and Sciences, Allahabad (U.P.), IN
1 Department of Molecular and Cellular Engineering, Sam Higginbottom Institute of Agriculture, Technology and Sciences, Allahabad (U.P.), IN
Source
Asian Journal of Bio Science, Vol 11, No 1 (2016), Pagination: 100-105Abstract
The Ataxia telangiectasia mutated gene encodes the ATM protein, a key element in the DNA damage response (DDR) signalling pathway responsible for maintaining genomic integrity within the cell. In order to study the genetic changes of ATM gene in Lukaemia, we collected the blood samples of healthy persons for control and leukaemia persons for disease samples. We isolated DNA and performed PCR to analyse by Gene sequencing. As a result we found less number of sequencing result in nucleotide BLAST due to which we are unable to detect the compared result of mutation. Larger and/or combined association studies are needed to conclude the result.