Asian Journal of Bio Science

Ashwini G. Dashputre ¹, Mrunalini S. Lotankar ¹, M. O. Lokhande ¹, B. A. Aglave ¹

Affiliations
1 Department of Biotechnology, H.P.T. Arts and R.Y.K. Science College, Nashik (M.S.), IN

Abstract

A prion is thought to be an infectious agent that according to current scientific consensus, is comprised entirely of a propagated, misfolded protein. The misfolded form of the prion protein has been implicated in a number of diseases in variety of mammals; include bovine spongiform encephalopathy (BSE, that is “Mad cow disease”) in cattle and Creutzfeldt Jacob disease (CDJ in humans). All hypothesized prion diseases affect the structure of the brain or other neural tissue and all are currently untreatable and are always fatal. In general usage, prion refers to the theoretical unit of infection. Scientifically speaking, PrP^c refers to the endogenous prion protein, which is found in multitude of tissues, while PrP^c refers to the misfolded form of PrP^c, and is responsible for the formation of amyloid plaques that lead to neurodeaeneration. Prions are hypothesized to infect and propagate by refolding abnormally into a structure, which is able to convert normal molecules of the protein into the abnormally structured form. All known prions induce the formation of an amyloid fold, in which the protein polymerizes into an aggregate consisting of tightly packed beta-sheets. This altered structure is extremely stable and accumulates in infected tissue, causing cell death and tissue damage. This stability means that prions are resistant to denaturation by chemical and physical agents, making disposal and containment of these particles difficult. Proteins showing prion-type behavior are also found in some fungi and this has been quite important in helping to understand mammalian prions. However, fungal prions don’t appear to cause disease in their hosts and may even confer an evolutionary advantage through a form of protein-based inheritance. The word prion is a portmanteau developed by combining the first two syllables of the words proteinacious and infectious (-on by analogy to virion).

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Mrunalini S. Lotankar ¹, Nupoor S. Sonawane ¹, M. O. Lokhnde ¹, B. A. Aglave ¹

Affiliations
1 Department of Biotechnology, H.P.T. Arts and R.Y.K. Science College, Nashik (M.S.), IN

Abstract

History is the story of the achievements of men and women, but it records relatively few outstanding names and events. Many important contributions were by people whose names have been forgotten and whose accomplishments have been lost in the longer and deeper shadows cast by those who caught the fancy of the chroniclers. It has been said that in science the credit goes to the one who convinces the world, not to the one who first had the idea. Women are also not the exception here. There are notable examples of exceptional women not being publicly acknowledged for their contributions.

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