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Development of Aseptic Renal Abscess in a Patient with Non-Small-Cell Lung Cancer with ALK Translocation during Crizotinib Treatment


Affiliations
1 Centro de Oncologia, Hospital Sirio-Libanes, Sao Paulo, Brazil
2 Radiologia Intervencionista, Hospital Sirio-Libanes, Sao Paulo, Brazil
3 Infectious Disease, Hospital Sirio-Libanes, Sao Paulo, Brazil
 

Background: Crizotinib is a tyrosine kinase inhibitor of ALK, MET and ROS1. In a safety database trial, it was suggested an association of Crizotinib with the development of renal cyst in patients with non-small-cell lung cancer (NSCLC). Aim: To report an uncommon side effect of Crizotinib in a patient with NSLC. Case Presentation: We report the case of a 68-year-old woman with NSCLC who developed bilateral progressive aseptic renal abscesses during Crizotinib treatment. Conclusion: Further studies may be necessary to determinate the risk of renal cyst development and the management of these complications.

Keywords

Non-Small-Cell Lung Cancer, Crizotinib, Renal Abscesses.
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  • Development of Aseptic Renal Abscess in a Patient with Non-Small-Cell Lung Cancer with ALK Translocation during Crizotinib Treatment

Abstract Views: 93  |  PDF Views: 14

Authors

Luciana Franco do Prado de Carvalho
Centro de Oncologia, Hospital Sirio-Libanes, Sao Paulo, Brazil
Andrea Kazumi Shimada
Centro de Oncologia, Hospital Sirio-Libanes, Sao Paulo, Brazil
Manuel Santos da Cruz Neto
Centro de Oncologia, Hospital Sirio-Libanes, Sao Paulo, Brazil
Lucila Soares da Silva Rocha
Centro de Oncologia, Hospital Sirio-Libanes, Sao Paulo, Brazil
Publio Cesar Cavalcante Viana
Radiologia Intervencionista, Hospital Sirio-Libanes, Sao Paulo, Brazil
Esper George Kallas
Infectious Disease, Hospital Sirio-Libanes, Sao Paulo, Brazil
Artur Katz
Centro de Oncologia, Hospital Sirio-Libanes, Sao Paulo, Brazil

Abstract


Background: Crizotinib is a tyrosine kinase inhibitor of ALK, MET and ROS1. In a safety database trial, it was suggested an association of Crizotinib with the development of renal cyst in patients with non-small-cell lung cancer (NSCLC). Aim: To report an uncommon side effect of Crizotinib in a patient with NSLC. Case Presentation: We report the case of a 68-year-old woman with NSCLC who developed bilateral progressive aseptic renal abscesses during Crizotinib treatment. Conclusion: Further studies may be necessary to determinate the risk of renal cyst development and the management of these complications.

Keywords


Non-Small-Cell Lung Cancer, Crizotinib, Renal Abscesses.