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Efficacy and Effectiveness of Drug Treatments in Amyotrophic Lateral Sclerosis: a Systematic Review with Meta-Analysis


Affiliations
1 State Secreariat of Health of Federal District, Brazil
2 School of Health Sciences, Brasilia-DF, Brazil
3 University Hospital of Brasilia, Brasilia-DF, Brazil
 

The results of published studies with various neuroprotectors seeking to preserve motor neuron function and improve survival in amyotrophic lateral sclerosis patients have poor evidence in humans, although there are several studies in animal models with positive results. A systematic review and meta-analysis of studies on drug treatment options and survival times in animal models and patients with amyotrophic lateral sclerosis from March, 2009 to March, 2015 was conducted. Four hundred eighty-nine (489) articles were found, and from these, we selected 30 preclinical 'in vivo' studies, 18 randomized controlled trials, and four systematic reviews. A meta-analysis confirmed the effectiveness of various drugs in improving the life span in preclinical trials, in particular, Resveratrol, which had a mean difference of 10.8 days (95% CI: 9.57 to 12.02), whereas no drug showed efficacy in clinical trials. The positive results of preclinical studies should be interpreted with caution because there is a mismatch between those results and the negative results in clinical trials.

Keywords

Amyotrophic Lateral Sclerosis (ALS), Motor Neuron Disease, Drug, Treatment.
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  • Efficacy and Effectiveness of Drug Treatments in Amyotrophic Lateral Sclerosis: a Systematic Review with Meta-Analysis

Abstract Views: 93  |  PDF Views: 12

Authors

Mirian Conceicao Moura
State Secreariat of Health of Federal District, Brazil
Maria Rita Carvalho Garbi Novaes
State Secreariat of Health of Federal District, Brazil
Yuri S. S. P. Zago
School of Health Sciences, Brasilia-DF, Brazil
Emanoel Junio Eduardo
School of Health Sciences, Brasilia-DF, Brazil
Luiz Augusto Casulari
University Hospital of Brasilia, Brasilia-DF, Brazil

Abstract


The results of published studies with various neuroprotectors seeking to preserve motor neuron function and improve survival in amyotrophic lateral sclerosis patients have poor evidence in humans, although there are several studies in animal models with positive results. A systematic review and meta-analysis of studies on drug treatment options and survival times in animal models and patients with amyotrophic lateral sclerosis from March, 2009 to March, 2015 was conducted. Four hundred eighty-nine (489) articles were found, and from these, we selected 30 preclinical 'in vivo' studies, 18 randomized controlled trials, and four systematic reviews. A meta-analysis confirmed the effectiveness of various drugs in improving the life span in preclinical trials, in particular, Resveratrol, which had a mean difference of 10.8 days (95% CI: 9.57 to 12.02), whereas no drug showed efficacy in clinical trials. The positive results of preclinical studies should be interpreted with caution because there is a mismatch between those results and the negative results in clinical trials.

Keywords


Amyotrophic Lateral Sclerosis (ALS), Motor Neuron Disease, Drug, Treatment.