Asian Journal of Chemistry and Pharmaceutical Sciences https://www.i-scholar.in/index.php/AJPAC Asian Journal of Chemistry and Pharmaceutical Science (AJCPS) is an open access international journal publishing original peer-reviewed research articles. The journal is a Quarterly Publication. AJCPS is an international journal dedicated to various disciplines of Chemical and Pharmaceutical sciences. The aim of the journal is to provide an international forum to Researchers, academicians and other professionals of concerning subject area, to share the knowledge of scientific advancements through a peer reviewed publication. Informatics Publishing Limited and Open Science Publishers en-US Asian Journal of Chemistry and Pharmaceutical Sciences Applied Study on Lipid Content and Fatty Acid Profile of Four Marine Macro Algae (Seaweeds) Collected from South East Coast of Sri Lanka https://www.i-scholar.in/index.php/AJPAC/article/view/178612 <p>The lipid content and fatty acid profile of four marine macro algae (<em>Ulva lactuca, Sargussum wightii, Sargussum turbinaria, </em>and <em>Kappaphycus alvarezii</em>) that are collected from south east coast of Sri Lanka were studied by solvent extraction followed by gas chromatographic analysis. The results indicated that, the saturated and unsaturated fatty acids levels from C4:0 to C22:6. The lipid content of the selected seaweeds varied from 0.49-1.51% and the highest lipid content was found in <em>U. lactuca </em>while the lowest lipid content was found in the <em>S. turbinaria</em>. The analysis of differences in the composition of the saturated to unsaturated fatty acids in the extracts, shown that, palmitic acid (C16:0) and linoleic acid (C18:2 cis 9, 12) reached the highest value in all selected seaweeds and the highest quantity of monounsaturated fatty acids was observed in <em>S. wightii </em>(18.35%) followed by <em>S. turbinaria </em>(15.32%) and <em>K. alvarezii </em>(15.20%). An omega-3 fatty acid such as, alpha linolenic acid (all-cis-6, 9, 12), linolenic acid (all-cis-9, 12, 15), and eicosatrienoic acid (all-cis-8, 11, 14) were rich in <em>U. lactuca, S. wightii </em>and <em>S. turbinaria. </em>But some seaweeds have been detected the butyric acid (C4:0) in higher proportion (5.58-28.94%) and it may due to the fermentation of the seaweeds. The obtained results helped to determine that selected seaweeds have higher content of saturated fatty acids than the unsaturated fatty acids and proper drying condition and storage condition will be need to the seaweeds.</p> G. D. T. M. Jayasinghe B. K. K. K. Jinadasa S. D. M. Chinthaka 2018-01-09 2018-01-09 3 Synthesis, Characterization and Anti-Bacterial Activity of Isatin Schiff Base Derivatives https://www.i-scholar.in/index.php/AJPAC/article/view/178613 <p>Initially, Isatin was treated with 4-amino acetanilide to form Isatin Schiff base, by the reaction of the free amino group on4-amino acetanilide with carbonyl group of Isatin in the presence of ethanol and glacial acetic acid with the elimination of water molecule. The obtained Isatin Schiff base was then treated with substituted aromatic aldehydes in the presence of potassium hydroxide and ethanol to form various Chalcone derivatives (<strong>C1</strong>-<strong>C7</strong>). The structures of the synthesized compounds (<strong>C1</strong>-<strong>C7</strong>) were examined and confirmed using IR, Mass spectroscopy, <sup>1</sup>H-NMR and elemental analysis. By agar disc diffusion method, all given compounds were evaluated for their anti-bacterial activity against four bacteria at concentrations 25, 50 and 100 μg/ml. <strong>C4 </strong>and <strong>C6</strong>, were discovered to have possessed the most potent anti-bacterial activity.</p> Justin Ebuka Ezekwem D. Visagaperumal Vineeth Chandy 2019-01-09 2019-01-09 3 Whey Protein and <i>Nigella sativa</i> Oil Mitigate Potassium Dichromate Induced Hepatic Injury, Oxidative Stress and Hematotoxicity in Rats https://www.i-scholar.in/index.php/AJPAC/article/view/178614 <p>The present study was carried out to evaluate the antioxidant property of whey protein and/or <em>Nigella sativa </em>Oil (NSO) against hepatotoxicity evoked by potassium dichromate(K<sub>2</sub>C<sub>r</sub>2O<sub>7</sub>). Designed for this purpose, we detected the 8 weeks challenge result of whey protein (100 and 200 mg/kg, p.o) with/or without <em>Nigella sativa </em>oil (5ml/kg, p.o) in contradiction of poisoned albino rats with one dose of potassium dichromate (30mg/Kg, I.P) at the end of challenge period. Concerning plasma level, whey protein with/or without <em>Nigella sativa </em>oil were ameliorated the potassium dichromate liver damage concerns, so it exhibited a major progress in Aspartate Aminotransferase (AST), Alanine Amino Transferase (ALT), Alkaline Phosphatase (ALP), and Gamma-Glutamyl Transferase (GGT). Moreover, whey protein or <em>Nigella sativa </em>oil reduce the deleterious effects of potassium dichromate on Triiodothyronine (T3), Thyroxine (T4), Thyroidstimulating Hormone (TSH), glucose and Complete Blood Count (CBC). In addition, they displayed an important improvement in hepatic antioxidant enzymes, Catalase (CAT) and Superoxide Dismutase (SOD) beside reduced Glutathione (GSH), and with a subsequent decrease in Malondialdehyde (MDA) or Nitric Oxide (NO) levels in comparison with the untreated K<sub>2</sub>C<sub>r</sub>2O<sub>7</sub> group. Also, whey protein with/or without <em>Nigella sativa </em>oil improve the histopathological alterations produced by the potassium dichromate. These outcomes suggest that whey protein or <em>Nigella sativa </em>oil can be used as effective antioxidant aginst potassium dichromate intoxication as they modulate liver function and decrease oxidative stress.</p> Samir A. E. Bashandy Mohamed M. Amin Salma A. El-Marasy Fatma A. A. Ibrahim Hafiza A. Sharaf 2019-01-09 2019-01-09 3